2-Chloro-6-methylpyridine Chemical Properties

Boiling point:

64-68 °C10 mm Hg(lit.)

Density 

1.167 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.527(lit.)

Flash point:

165 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

1.10±0.10(Predicted)

form 

Liquid

color 

Clear colorless to light yellow

Specific Gravity

1.167

BRN 

107187

InChI

InChI=1S/C6H6ClN/c1-5-3-2-4-6(7)8-5/h2-4H,1H3

InChIKey

GXZDYRYYNXYPMQ-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(C)=CC=C1

CAS DataBase Reference

18368-63-3(CAS DataBase Reference)

NIST Chemistry Reference

2-Cl-6-(CH3)-pyridine(18368-63-3)

EPA Substance Registry System

Pyridine, 2-chloro-6-methyl- (18368-63-3)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

RIDADR 

UN2810

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:2-Chloro-6-methylpyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Chloro-6-methylpyridine Usage And Synthesis

Description

2-Chloro-6-methylpyridine (2C6MP) is a strong inhibitor of methane monooxygenase, a key enzyme in the aerobic oxidation of methane (CH4). It belongs to the pesticide nitropyridine group of compounds. Studies have shown that 2C6MP has the least effect on CH4 oxidation at concentrations of 0.1 mM and 1 mM, but at a concentration of 10 mM, 2C6MP inhibits CH4 oxidation for >20 months. Low concentrations of 2C6MP did not inhibit Methylophilaceae, while high concentrations of 2C6MP inhibited Methylophilaceae by only 7.8 ± 1.1%^[1].

Chemical Properties

Light yellow liquid

Uses

2-Chloro-6-methylpyridine has been used for experimental FTIR and FT-Raman spectroscopic analyses, as well as for conformational studies.

References

[1] E. O’LOUGHLIN. Inhibition of Microbial Methane Oxidation by 2-Chloro-6-Methylpyridine[J]. bioRxiv?: the preprint server for biology, 2022. DOI:10.1101/2022.10.13.512149.

2-Chloro-6-methylpyridine(18368-63-3)Related Product Information

• Azamethiphos
• 2-Picoline
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 4-Methylpyridine
• 2-Chloro-6-methoxypyridine
• 2,5-Dimethylpyridine
• 5-Amino-2-methylpyridine
• 2-(Chloromethyl)pyridine
• Nitrapyrin
• Clopyralid
• 2-CHLORO-6-METHYLPYRIDINE-4-CARBOXYLIC ACID
• 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine
• Picloram
• 2-Chloro-3-cyano-4,6-dimethylpyridine
• 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE
• 2-Chloro-6-methyl-3-pyridinecarbonitrile
• Difluorochloromethane