Betanidine
Betanidine Basic information
- Product Name:
- Betanidine
- Synonyms:
-
- Betanidine
- Bethanidine
- 1-Benzyl-2,3-dimethylguanidine
- N,N'-Dimethyl-N''-(phenylmethyl)guanidine
- 2-benzyl-1,3-diMethylguanidine
- BETANIDIN
- Guanidine, N,N''-dimethyl-N'-(phenylmethyl)-
- Betanidine USP/EP/BP
- CAS:
- 55-73-2
- MF:
- C10H15N3
- MW:
- 177.25
- Mol File:
- 55-73-2.mol
Betanidine Chemical Properties
- Melting point:
- 195-197°
- Boiling point:
- 299.18°C (rough estimate)
- Density
- 0.9826 (rough estimate)
- refractive index
- 1.4800 (estimate)
- pka
- pKa 10.6 (Uncertain)
Betanidine Usage And Synthesis
Originator
Bendogen,Lagap Pharmaceuticals SA
Uses
Betanidine is a betacyanin and an aglycone of the beet dye betanin.
Definition
ChEBI: Bethanidine is a member of guanidines. It has a role as an adrenergic antagonist and an antihypertensive agent.
Manufacturing Process
A mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate (10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood, during which methylmercaptan escaped (as evidenced by a foul odour). The reaction mixture was then cooled and diluted with ethanol (100 ml). A colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed with ethanol. This solid melted at 230-232°C; it was recrystallized from water and then melted at 247-248°C. By action of a basic agent the salt obtained may be converted into free base.
Therapeutic Function
Antihypertensive
Betanidine(55-73-2)Related Product Information
- Betanidine
- 2-(6-OXO-4-PHENYL-1,6-DIHYDRO-2-PYRIMIDINYL)-1,2,4,5,6,7-HEXAHYDRO-3H-INDAZOL-3-ONE
- BUTTPARK 111\40-81
- 6-(2-FLUOROPHENYL)-2-[4-(2-HYDROXYETHYL)-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL]-4(3H)-PYRIMIDINONE
- N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(3-METHYLPHENYL)AMINO]METHYLENE}BENZAMIDE
- N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(4-METHOXYPHENYL)AMINO]METHYLENE}BENZAMIDE
- 2-(4-BENZYL-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE
- behenyltrimethylammonium methosulfate
- N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(2-METHOXYPHENYL)AMINO]METHYLENE}BENZAMIDE
- BUTTPARK 111\40-79
- N-{(1E)-ANILINO[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO]METHYLENE}BENZAMIDE
- 2-[4-(2-HYDROXYETHYL)-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL]-6-PHENYL-4(3H)-PYRIMIDINONE
- BUTTPARK 111\40-77
- RARECHEM AQ NN 0471
- 2-(5-OXO-3-PHENYL-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE
- (E)-N-((3-CHLOROPHENYLAMINO)(4,6-DIMETHYLPYRIMIDIN-2-YLAMINO)METHYLENE)-3,4,5-TRIMETHOXYBENZAMIDE
- BUTTPARK 111\40-78
- BUTTPARK 111\40-44