Rutamycin Chemical Properties

Melting point:

116-119°

alpha 

D20 -62° (c = 1.36 in CHCl3)

Boiling point:

883.4±65.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble

form 

A lyophilisate

pka

12.52±0.70(Predicted)

Safety Information

RIDADR 

2811

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

LD50 oral in mouse: 800mg/kg

Rutamycin Usage And Synthesis

Description

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F₁F_O-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC₅₀ value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC₅₀ value of 36 μM.

Uses

Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

Uses

Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase.

References

[1] INOUE S. Purification and Characterization of a Novel Protein Activator of Ca2+/Calmodulin-Dependent Protein Kinase I[J]. Biochemical and biophysical research communications, 1995, 215 3: Pages 861-867. DOI: 10.1006/bbrc.1995.2543
[2] SALIM A A, TAN L, HUANG X C, et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation?[J]. Organic & Biomolecular Chemistry, 2015, 2: 711-715. DOI: 10.1039/c5ob02020d

Rutamycin(1404-59-7)Related Product Information

• Chloramphenicol
• Natamycin
• OLIGOMYCIN
• Rutamycin