Saccharin sodium dihydrate Chemical Properties

Melting point:

> 300℃

Flash point:

>200°C

storage temp. 

2-8°C

solubility 

1000g/l

form 

powder to crystaline

color 

White to Almost white

PH

6.0-7.5 (100g/l, H2O, 20℃)

Water Solubility 

Soluble in water. Slightly soluble in alcohol

Merck 

14,8311

InChI

InChI=1S/C7H5NO3S.Na.H2O.H/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;;;/h1-4H,(H,8,9);;1H2;

InChIKey

BCWVKFPXENUOQA-UHFFFAOYSA-N

SMILES

O=S1(NC(=O)C2C=CC=CC1=2)=O.[NaH].O

CAS DataBase Reference

6155-57-3(CAS DataBase Reference)

Safety Information

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

2

RTECS 

DE4375000

TSCA 

Yes

HS Code 

29350090

Toxicity

LD50 orally in Rabbit: 14200 mg/kg

MSDS

• Language:English Provider:Sodium ortho-sulphobenzimide dihydrate
• Language:English Provider:ALFA

Saccharin sodium dihydrate Usage And Synthesis

Description

Saccharin sodium dihydrate is the sodium dihydrate form of saccharin, which belongs to the family of aromatic homomonocyclic compounds. It is an artificial sweetener that is hundreds times as sweet as sucrose. It is mainly used as a food additive to sweeten many products such as drinks, candies, cookies, and medicine. Saccharin is relatively safe for human beings without providing food energy and any nutritional value. It is also safe for diabetes patients to consume.

Chemical Properties

dihydrate granular

Chemical Properties

Saccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.

Uses

Sweetener (non-nutritive).

Uses

Saccharin Sodium Salt Dihydrate is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.

Production Methods

Saccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.

brand name

Sucaryl (Ross).

Pharmaceutical Applications

Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.

Safety

There has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg

storage

Saccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.

Incompatibilities

Saccharin sodium does not undergo Maillard browning.

Regulatory Status

Accepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

References

https://en.wikipedia.org/wiki/Saccharin
https://pubchem.ncbi.nlm.nih.gov/compound/saccharin#section=Top

Saccharin sodium dihydrate(6155-57-3)Related Product Information

• Saccharin sodium
• Sodium benzoate
• N,N'-1,3-Phenylene bismaleimide
• 2-Methoxyphenylacetic acid
• O-Phthalimide
• Diclofenac sodium
• Trisodium phosphate
• Phenylmethylsulfonyl fluoride
• Phthalhydrazide
• Saccharin
• Sodium acetate
• Sodium bicarbonate
• Sodium hydroxide
• Sodium N-cyclohexylsulfamate
• SACCHARIN SODIUM SALT DIHYDRATE
• 2-Nitrobenzenesulfonyl chloride
• 1,2-Benzisothiazol-3(2H)-one
• FOROXYMITHINE