1-BROMO-2,3,5,6-TETRAFLUOROBENZENE Chemical Properties

Boiling point:

143-143.5 °C(lit.)

Density 

1.883 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.469(lit.)

Flash point:

129 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Almost colorless

Specific Gravity

1.883

Water Solubility 

Not miscible or difficult to mix in water.

CAS DataBase Reference

1559-88-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

10-36/37/38-22

Safety Statements 

16-26-36/37/39-37/39

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-BROMO-2,3,5,6-TETRAFLUOROBENZENE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

1-Bromo-2,3,5,6-tetrafluorobenzene is used to produce 1,2,4,5-tetrafluoro-3-hept-1-ynyl-benzene. It is also used as a pharmaceutical intermediate.

Synthesis

Potassium salt of 2,3,5,6-tetrafluorobenzoic acid (100 g) was added to dimethylformamide (250 ml) and stirred in a glass reactor equipped with a mechanical stirrer, a dropping funnel, a separator, a Liebig condenser, an adapter and a receiving flask, the reaction mixture was heated to 140 ??C and bromotrichloromethane (85 g) was added in such a way as to maintain a 140-143 ??C temperature while distilling out the resulting product. This process was continued until the end of the outgassing. The distillate was mixed with the cube and washed with two volumes of 15% perchloric acid. The lower (organic) layer was separated, hydrodistilled, then dried and distilled with CaCl2. 1-Bromo-2,3,5,6-tetrafluorobenzene (89 g) was obtained with a boiling point of 144??C and a yield of 91%.

1-BROMO-2,3,5,6-TETRAFLUOROBENZENE(1559-88-2)Related Product Information

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