Sildenafil Chlorosulfonyl Chemical Properties

Melting point:

180-182°C

Density 

1.48±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly, Heated)

form 

Solid

pka

9.87±0.20(Predicted)

color 

White to Pale Beige

Stability:

Moisture Sensitive

InChI

InChI=1S/C17H19ClN4O4S/c1-4-6-12-14-15(22(3)21-12)17(23)20-16(19-14)11-9-10(27(18,24)25)7-8-13(11)26-5-2/h7-9H,4-6H2,1-3H3,(H,19,20,23)

InChIKey

RVVOSOSBFSYZDM-UHFFFAOYSA-N

SMILES

C1(S(Cl)(=O)=O)=CC=C(OCC)C(C2NC(=O)C3N(C)N=C(CCC)C=3N=2)=C1

CAS DataBase Reference

139756-22-2

Safety Information

HS Code 

2933599590

Sildenafil Chlorosulfonyl Usage And Synthesis

Description

Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil. It is also a potential impurity found in commercial preparations of sildenafil.

Chemical Properties

Off-White Solid

Uses

The compound Sildenafil Chlorosulfonyl Impurity (139756-22-2) is a derivative of Sildenafil. It is widely used in the treatment of pulmonary hypertension as it is capable of inhibiting cGMP and acts as a potent selective inhibitor of PDE5.

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