trans Resveratrol 3-O-β-D-Glucuronide Chemical Properties

Melting point:

>150C (dec.)

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Beige

biological source

synthetic

Stability:

Hygroscopic

Safety Information

HS Code 

2938909090

trans Resveratrol 3-O-β-D-Glucuronide Usage And Synthesis

Description

Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. In humans, resveratrol is almost completely conjugated to its glucuronide and sulfate metabolites. trans-Resveratrol-3-O-β-D-glucuronide is a regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.

Chemical Properties

Off-White Solid

Uses

Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. In humans, resveratrol is almost completely conjugated to its glucuronide and sulfate metabolites. trans-Resveratrol-3-O-β-D-glucuronide is a regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.

Uses

A metabolite of trans Resveratrol (R150000).

Definition

ChEBI: Trans-Resveratrol 3-O-glucuronide is a stilbenoid and a glycoside.

References

[1] G A POTTER. The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1[J]. British Journal of Cancer, 2002, 86 5: 774-778. DOI: 10.1038/sj.bjc.6600197
[2] VIRGINIE AUMONT . Regioselective and Stereospecific Glucuronidation of trans- and cis-Resveratrol in Human[J]. Archives of biochemistry and biophysics, 2001, 393 2: Pages 281-289. DOI: 10.1006/abbi.2001.2496
[3] BARBARA CALAMINI. Pleiotropic mechanisms facilitated by resveratrol and its metabolites.[J]. Biochemical Journal, 2010, 429 2: 273-282. DOI: 10.1042/bj20091857
[4] ELENA POLYCARPOU. Resveratrol 3-O-d-glucuronide and resveratrol 4′-O-d-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest[J]. Molecular Nutrition & Food Research, 2013, 57 10: 1708-1717. DOI: 10.1002/mnfr.201200742
[5] MELLINA S. SIMES . Resveratrol biotransformation and actions on the liver metabolism of healthy and arthritic rats[J]. Life sciences, 2022, 310: Article 120991. DOI: 10.1016/j.lfs.2022.120991

trans Resveratrol 3-O-β-D-Glucuronide(387372-17-0)Related Product Information

• 3,4',5-TRIMETHOXY-TRANS-STILBENE
• Resveratrol
• CIS-TRIMETHOXY STILBENE
• Dihydroresveratrol
• trans Resveratrol 4O-b-D-Glucuronide
• cis Resveratrol
• Azo-Resveratrol
• trans/cis Resveratrol-D4
• Oxyresveratrol
• Resveratrol-13C6
• 3,5-DIHYDROXY-4'-METHOXYSTILBENE 3-O-BETA-D-GLUCOSIDE
• 4'-Methoxyresveratrol
• PICEATANNOL
• 3,5-DIHYDROXY-4'-BROMOSTILBENE
• Acetyl-trans-resveratrol
• trans Resveratrol 3-Sulfate
• Resveratrol 3-Sulfat-4’glucuronide
• trans Resveratrol-3,5-disulfate