Clanfenur Chemical Properties

Density 

1.371±0.06 g/cm3(Predicted)

solubility 

Acetonitrile: Slightly soluble: 0.1-1 mg/mL
DMSO: Sparingly soluble: 1-10 mg/mL

form 

Solid

pka

9.37±0.46(Predicted)

color 

White to off-white

Clanfenur Usage And Synthesis

Uses

Clanfenur is a substituted benzoylphenylurea, an analogue of the pesticide fenfluramide, with potential antineoplastic activity. Clanfenur can bind to the colchicine-binding site on β-tubulin, inhibit microtubule polymerization, and thus prevent tumor cell replication[1].

References

[1] J D Jonkman-de Vries, et al. Pharmaceutical development of a parenteral formulation of the investigational anticancer drug clanfenur. PDA J Pharm Sci Technol. 1997 Mar-Apr;51(2):89-95. PMID:9146040
[2] H P HOFS  J G M. Effects of benzoylphenyl ureas on growth of B16 melanoma cells in vitro and in vivo.[J]. Investigational New Drugs, 1991, 9 3: 227-232. DOI: 10.1007/bf00176975
[3] V K JENKINS. Effects of diflubenzuron and clanfenur on mouse bone marrow cells.[J]. Investigational New Drugs, 1993, 11 4: 279-289. DOI: 10.1007/bf00874426

Clanfenur(51213-99-1)Related Product Information

• Edoxaban Impurity 38
• 2-(((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)amino)-2-oxoacetic acid
• carbamic acid, n-[(1r,2r,5s)-5-[(dimethylamino)carbonyl]-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester
• EthanediaMide, N1-(5-chlo...
• edoxaban
• (1S,3R,4S)-4-(2-((5-chloropyridin- 2-yl)amino)-2-oxoacetamido)-3-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexane-1-carboxylic acid
• (1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate
• tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate
• 2-Amino-5-chloropyridine
• Edoxaban Impurity 42
• Edoxaban Impurity 37
• (1R,3S,4R)-3-Amino-4-hydroxy-cyclohexanecarboxylic acid ethyl ester hydrochloride
• Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride
• 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
• Edoxaban Impurity 12 (1R,2R,4S)
• Edoxaban Impurity 45
• Edoxaban Impurity 23
• Edoxaban Impurity 35