Febrifugine Chemical Properties

Melting point:

139-140°; mp 154-156°

alpha 

D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol)

Density 

1.39

storage temp. 

2-8°C

solubility 

DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml

form 

A crystalline solid

Boiling point:

508.2±60.0 °C(Predicted)

pka

14.61±0.40(Predicted)

color 

White to off-white

CAS DataBase Reference

24159-07-7

Safety Information

Toxicity

LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949)

Febrifugine Usage And Synthesis

Description

Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.

Uses

Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.

Febrifugine(24159-07-7)Related Product Information

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