Naxagolide
Naxagolide Basic information
- Product Name:
- Naxagolide
- Synonyms:
-
- (+)-4-Propyl-9-hydroxynaphoxazine
- (4aR)-3,4,4aβ,5,6,10bα-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol
- 4-Propyl-9-hydroxynaphoxazine
- L-64739
- 2H-Naphth(1,2-B)-1,4-oxazin-9-ol, 3,4,4A,5,6,10B-hexahydro-4-propyl-, (4ar-trans)-
- Naxagolida
- Naxagolida [inn-spanish]
- Naxagolide [inn]
- CAS:
- 88058-88-2
- MF:
- C15H21NO2
- MW:
- 247.336
- EINECS:
- 200-258-5
- Mol File:
- 88058-88-2.mol
Naxagolide Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 200 mg/mL (808.64 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
Naxagolide Usage And Synthesis
Uses
Antiparkinsonian;dopamine agonist.
Definition
ChEBI: Naxagolide is an organic heterotricyclic compound that is (4aR,10bR)-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine substituted by propyl and hydroxy groups at positions 4 and 9, respectively. It is a potent dopamine D2-receptor agonist and its hydrochloride salt was under clinical development by Merck & Co as a potential antiparkinsonian agent (now discontinued). It has a role as an antiparkinson drug, a dopamine agonist and an anticonvulsant. It is a tertiary amino compound, an organic heterotricyclic compound and a member of phenols. It is a conjugate base of a naxagolide(1+).
in vivo
In mice, Naxagolide ((+)-PHNO) produces hypothermia (13 μg/kg i.p.) and postural asymmetry in the unilaterally caudectomized animal (4 μg/kg i.p.)[1].
In the rat, Naxagolide ((+)-PHNO) produces stereotypy (10 μg/kg i.p.) and contralateral turning in 6-hydroxydopamine-lesioned animals (5 μg/kg i.p.) that lasted 1 to 3 hr[1].
IC 50
D2 Receptor
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Naxagolide(88058-88-2)Related Product Information
- 3-PROPYLMORPHOLINE
- CIS-3,4-DIMETHYL-2-PHENYLMORPHOLINE
- 2-O-TOLYL-MORPHOLINE
- (S)-4-(3-AMINO-BUTYL)-PHENOL
- Phenylephrine hydrochloride
- (-)-Pseudoephedrine
- 7-AMINO-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-OL
- (1R,2R)-(-)-N-METHYLPSEUDOEPHEDRINE
- 3-Ethylmorpholine hydrochloride
- Phenmetrazine
- (R)-2-Methyl-morpholine
- (+)-3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol, Hydrochloride
- (R)-3-Methylmorpholine
- Naxagolide