Risedronic acid Chemical Properties

Melting point:

>232°C (subl.)

Boiling point:

692.3±65.0 °C(Predicted)

Density 

1.870±0.06 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)

form 

Solid

pka

1.41±0.10(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

CAS DataBase Reference

105462-24-6(CAS DataBase Reference)

EPA Substance Registry System

Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6)

Safety Information

Hazardous Substances Data

105462-24-6(Hazardous Substances Data)

Risedronic acid Usage And Synthesis

Uses

Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. It is a potentially useful biophosphonate for bone resorption analysis.

Definition

ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.

Mode of action

Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.

Risedronic acid(105462-24-6)Related Product Information

• Amino tris(methylene phosphonic acid)
• Stearic acid
• Citric acid
• Ethanol
• Ethylparaben
• Folic acid
• Hyaluronic acid
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• ISOXADIFEN-ETHYL
• Trinexapac-ethyl
• 2-Ethoxyethanol
• Ethyl acetate
• Zoledronic acid
• Disodium pamidronate
• Ethyl 2-(Chlorosulfonyl)acetate
• CHLOROPHOSPHONAZO III
• Ascoric Acid
• Diethyl ether