Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Organic Chemistry >  Phosphines >  Risedronic acid

Risedronic acid

Basic information Safety Supplier Related

Risedronic acid Basic information

Product Name:
Risedronic acid
Synonyms:
  • 1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid
  • RISEDRONIC ACID: RISEDRONIC ACID MONOHYDRATE
  • 1-Hydroxy-2-(3-pyridinyl)ethylidenebisphosphonicacidmonohydrate
  • 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE]BISPHOSPHONIC ACID
  • 3-(Acetic acid)Pyridine
  • Risedronic acid(Sodium risedronate intermediate)
  • Phosphonic acid,P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-
  • P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid
CAS:
105462-24-6
MF:
C7H11NO7P2
MW:
283.11
EINECS:
600-654-2
Product Categories:
  • API
  • (intermediate of risedronate sodium
  • Risedronate
Mol File:
105462-24-6.mol
More
Less

Risedronic acid Chemical Properties

Melting point:
>232°C (subl.)
Boiling point:
692.3±65.0 °C(Predicted)
Density 
1.870±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form 
Solid
pka
1.41±0.10(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey
IIDJRNMFWXDHID-UHFFFAOYSA-N
SMILES
C(P(=O)(O)O)(P(=O)(O)O)(O)CC1=CC=CN=C1
CAS DataBase Reference
105462-24-6(CAS DataBase Reference)
EPA Substance Registry System
Phosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6)
More
Less

Safety Information

Hazardous Substances Data
105462-24-6(Hazardous Substances Data)
More
Less

Risedronic acid Usage And Synthesis

Uses

Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. It is a potentially useful biophosphonate for bone resorption analysis.

Definition

ChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.

in vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b2.
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with?Plasmodium berghei?strain ANKA, but does not prolong the survival time of mice3.

Animal Model:Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body2
Dosage:30 μg/kg
Administration:Subcutaneous injection, once every other day, for 3 weeks
Result:Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.
Animal Model:Male BALB/c mice (3-4 weeks old) infected with?Plasmodium berghei?strain ANKA by intraperitoneal injection of?1×106?blood-stage parasites3
Dosage:10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:Intraperitoneal injection, once a day, for 7 days
Result:Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.

Mode of action

Risedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.

Risedronic acidSupplier

changzhoubaotuobiochemical&pharm、LTD. Gold
Tel
0519-13912326059 13912326059
Email
alona1979@163.com
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
Energy Chemical
Tel
021-021-58432009 400-005-6266
Email
sales8178@energy-chemical.com
More
Less

Risedronic acid(105462-24-6)Related Product Information