Asiaol-Gm1-tetrasaccharide
Asiaol-Gm1-tetrasaccharide Basic information
- Product Name:
- Asiaol-Gm1-tetrasaccharide
- Synonyms:
-
- Asiaol-Gm1-tetrasaccharide
- Gangliotetraose
- D-Glucose, O-β-D-galactopyranosyl-(1→3)-O-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl-(1→4)-O-β-D-galactopyranosyl-(1→4)-
- Asialo GM1 Ganglioside oligosaccharide (aGM1) grafted on BSA Sodium salt
- Asialo GM1 Ganglioside oligosaccharide (aGM1) linked to biotin (Linker-BT A) Sodium salt
- Asialo GM1 Ganglioside oligosaccharide (aGM1) linked to biotin (Linker-BT B) Sodium salt
- Asialo GM1 Ganglioside oligosaccharide (aGM1) linked to biotin (Linker-BT C) Sodium salt
- Asialo GM1 Ganglioside oligosaccharide (aGM1) linked to biotin and fluorescein (Linker-BT-FLUO A) Sodium salt
- CAS:
- 75645-24-8
- MF:
- C26H45NO21
- MW:
- 707.63
- Mol File:
- 75645-24-8.mol
Asiaol-Gm1-tetrasaccharide Chemical Properties
- Boiling point:
- 1173.6±65.0 °C(Predicted)
- Density
- 1.72±0.1 g/cm3(Predicted)
- pka
- 12.39±0.20(Predicted)
Asiaol-Gm1-tetrasaccharide Usage And Synthesis
Uses
Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2].
in vivo
Gangliotetraose (GM1) (30 mg/kg; i.p.; 5, 11, 42, and 73 d) stimulates the regeneration of nigrostriatal dopaminergic neurons in the central nervous system of rats after unilateral hemitransection[5].
| Animal Model: | Unilateral semi-transection model in Sprague-Dawley rats (170-190 g)[5] |
| Dosage: | 5 mg/kg; 30 mg/kg |
| Administration: | Intraperitoneal injection; 5, 11, 42, 73 days; started on day 2 after surgery and finished 24 h before sacrifice |
| Result: | Increased the Vmax of tyrosine hydroxylase (TH) in the lesioned side starting on day 14 dose-dependently with 73% (5 mg/kg/d) and 85% (30 mg/kg/d) of that of the unlesioned side, respectively. |
References
[1] Okada H, et al. Complement-mediated cytolysis and azidothymidine are synergistic in HIV-1 suppression. Int Immunol. 1998 Jan;10(1):91-5. DOI:10.1093/intimm/10.1.91
[2] Ledeen RW, et al. The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding. Ann N Y Acad Sci. 1998 Jun 19;845:161-75. DOI:10.1111/j.1749-6632.1998.tb09669.x
[3] Zakharova IO, et al. GM1 ganglioside activates ERK1/2 and Akt downstream of Trk tyrosine kinase and protects PC12 cells against hydrogen peroxide toxicity. Neurochem Res. 2014 Nov;39(11):2262-75. DOI:10.1007/s11064-014-1428-6
[4] Toffano G, et al. GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system. Brain Res. 1983 Feb 14;261(1):163-6. DOI:10.1016/0006-8993(83)91298-2
Asiaol-Gm1-tetrasaccharideSupplier
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Tel
- 16314854226
- inquiry@bocsci.com
- Tel
- +1-631-485-4226
- inquiry@bocsci.com
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Tel
- 15102117276 19921389125
- tech@zzbioco.com