5-Aminoindole Chemical Properties

Melting point:

131-133 °C (dec.) (lit.)

Boiling point:

190 °C / 6mmHg

Density 

1.1083 (rough estimate)

refractive index 

1.6013 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO, Methanol

pka

17.39±0.30(Predicted)

form 

Crystalline Powder

color 

Off-white to gray-brown

Water Solubility 

insoluble

Sensitive 

Air & Light Sensitive

BRN 

112348

InChIKey

ZCBIFHNDZBSCEP-UHFFFAOYSA-N

CAS DataBase Reference

5192-03-0(CAS DataBase Reference)

NIST Chemistry Reference

5-Aminoindole(5192-03-0)

EPA Substance Registry System

5-Aminoindole (5192-03-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-68

Safety Statements 

26-45-36/37

WGK Germany 

3

F 

10

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

AIR SENSITIVE, IRRITANT-HARMFUL, KEEP COLD

HS Code 

29339990

MSDS

• Language:English Provider:5-Aminoindole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5-Aminoindole Usage And Synthesis

Chemical Properties

Grey Crystals

Uses

Reactant for preparation of:

• Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP
• Cytotoxic and antimitotic agents
• Insulin-like growth factor 1 receptor inhibitors
• Antitumoral agents
• Factor Xa inhibitor
• Potential antivascular agents
• Gli1-mediated transcription in the Hedgehog pathway
• Inhibitors of receptor tyrosine kinase with antiangiogenic effects
• PKCθ inhibitors
• HIV protease inhibitors

Uses

5-Aminoindole functions as a ligand for hydrophobic charge induction chromatography. A reagent for synthetic elaboration.

Definition

ChEBI: An indolamine carrying an amino group at position 5.

5-Aminoindole(5192-03-0)Related Product Information

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• Indole
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• REMASTRAL BLUE FFRL
• 4-Aminoindole;4-Indolamine
• 4-(3-CARBAZOLYLAMINO)PHENOL
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• 2-METHYL-5-NITROINDOLE
• 1,3,6,8-TETRANITROCARBAZOLE
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• 2,3-DIMETHYL-5-NITROINDOLE
• 5-Nitroindole
• 9-Ethyl-3-nitrocarbazole
• 5-Nitroisatin