GLY-ARG-GLY-ASP-SER-PRO-LYS Chemical Properties

Density 

1.59±0.1 g/cm3(Predicted)

storage temp. 

-20°C

form 

Solid

pka

3.60±0.21(Predicted)

color 

White to off-white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GLY-ARG-GLY-ASP-SER-PRO-LYS Usage And Synthesis

Uses

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-

• as a blocking peptide to inhibit integrin-fibronectin binding
• in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
• for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
• for the preparation of RGD.Flt23k.NR nanoparticles
• to determine the involvement of RGD-integrin bonding in cell adhesion process

General Description

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.

Biochem/physiol Actions

Fibronectin analog that binds to integrins.

GLY-ARG-GLY-ASP-SER-PRO-LYS(111119-28-9)Related Product Information

• ARG-GLY-ASP-SER
• GLY-ARG-GLY-ASP-SER
• GLY-ARG-GLY-ASP
• ARG-GLY-ASP
• 1-ADAMANTANEACETYL-CYS-GLY-ARG-GLY-*ASP-SER-PRO-LYS
• GLY-ARG-ALA-ASP-SER-PRO-LYS
• acetyl-arginyl-glycyl-aspartyl-serinamide
• H-ALA-ALA-PRO-ALA-OH
• GLY-ARG-GLY-ASP-SER-PRO-LYS
• H-ALA-PRO-ALA-OH
• L-LYSINE ACETATE SALT