Ertapenem sodium Chemical Properties

Melting point:

>174oC (dec.)

storage temp. 

-70°C

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)

form 

powder

color 

white to beige

Water Solubility 

Fully miscible in water. Soluble in DMSO.

Stability:

Hygroscopic, Temperature Sensitive

Ertapenem sodium Usage And Synthesis

Uses

Ertapenem sodium has been used as a carbapenem in the NitroSpeed-Carba NP test in minimum inhibitory concentration (MIC) testing for differentiation of carbapenemases in Enterobacterales and Pseudomonas aeruginosa. It has also been used as an antibiotic to study its effects on the survival of septic mice.

Definition

ChEBI: The monosodium salt of ertapenem. It is used for the treatment of moderate to severe susceptible infections including intra-abdominal and acute gynaecological infections, pneumonia, and infections of the skin and of the urinary tract. It is more stable to renal dehydropeptidase I tham imipenem, and so unlike imipenem, its use with cilastatin, which inhibits the enzyme, is not required.

Biochem/physiol Actions

Ertapenem is a broad spectrum carbopenem antibiotic. Ertapenem is active against both gram-positive and gram-negative bacteria. Ertapenem shows an extended duration of action in vivo due to its reversible binding to serum protein.

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