Decursinol
Decursinol Basic information
- Product Name:
- Decursinol
- Synonyms:
-
- (7S)-7α-Hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one
- (S)-7,8-Dihydro-7-hydroxy-8,8-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one
- Decursinol
- (3S)-3-Hydroxy-2,2-dimethyl-3,4-dihydropyrano[3,2-g]chromen-8-one
- 2H,6H-Benzo[1,2-b:5,4-b']dipyran-2-one,7,8-dihydro-7-hydroxy-8,8-dimethyl-, (7S)-
- ecursinol
- Decursinol,inhibit,Inhibitor
- (S)-7-Hydroxy-8,8-dimethyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
- CAS:
- 23458-02-8
- MF:
- C14H14O4
- MW:
- 246.26
- Mol File:
- 23458-02-8.mol
Decursinol Chemical Properties
- Melting point:
- 178 °C
- Boiling point:
- 433.6±45.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMF: 30 mg/ml; DMSO: 15 mg/ml; Ethanol: slightly soluble
- form
- A solid
- pka
- 13.87±0.40(Predicted)
- color
- White to off-white
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
ANTIOXIDANT - InChI
- 1S/C14H14O4/c1-14(2)12(15)6-9-5-8-3-4-13(16)17-10(8)7-11(9)18-14/h3-5,7,12,15H,6H2,1-2H3/t12-/m0/s1
- InChIKey
- BGXFQDFSVDZUIW-LBPRGKRZSA-N
- SMILES
- [o]1c2c(cc3c(c2)OC([C@H](C3)O)(C)C)cc[c]1=O
- CAS DataBase Reference
- 23458-02-8
Decursinol Usage And Synthesis
Uses
Decursinol, isolated from the roots of Angelica gigas, possesses antinociceptive effect with orally bioavailability. Decursinol possesses anti-tumor and anti-metastasis activity[1].
Definition
ChEBI: An organic heterotricyclic compound that is 7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-2-one substituted by a beta-hydroxy group at position 7 and two methyl groups at position 8. It is isolat d from the roots of Angelica gigas and has been found to possess significant inhibitory activity against acetylcholinesterase enzyme (EC 3.1.1.7).
References
[1] Choi SS, et al. Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sci. 2003 Jun 13;73(4):471-85. DOI:10.1016/s0024-3205(03)00311-4
[2] Son SH, et al. Decursin and decursinol from Angelica gigas inhibit the lung metastasis of murine colon carcinoma. Phytother Res. 2011 Jul;25(7):959-64. DOI:10.1002/ptr.3372
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