2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate Chemical Properties

storage temp. 

Desiccate at -20°C

solubility 

Soluble to 100 mM in DMSO and to 100 mM in ethanol

form 

Powder

2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate Usage And Synthesis

Uses

PCA 4248 is a competitive inhibitor of PAF at the PAF-R level.

Definition

ChEBI: 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-[2-(phenylthio)ethyl] ester is a dihydropyridine.

Biological Activity

A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC 50 value of 1.05 μ M and has no significant activity on Ca 2+ channels. Active in vivo , antagonising PAF-induced systemic hypotension and protein-plasma extravasation in rats.

2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate(123875-01-4)Related Product Information

• dimethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate
• 2-(Phenylthio)Ethyl Acrylate
• 2-phenylsulfanylethyl methyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-d icarboxylate
• 2,4-DIMETHYL-1,4-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• 2-(METHYLTHIO)ETHYL METHACRYLATE