palitantin Chemical Properties

Melting point:

169℃ (ethyl acetate )

alpha 

235461 +4.4° (c = 0.8 in CHCl3)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

White solid.

color 

White

palitantin Usage And Synthesis

Description

Palitantin is a fungal metabolite originally isolated from P. palitans. It inhibits HIV-1 integrase with IC₅₀ values of 350 and 268 μM for 3’-processing and strand transfer activity, respectively. Palitantin has been used as a standard for dereplication of natural products.

Uses

Palitantin is an antifungal and antiprotozoal compound.

IC 50

Leishmania; Fungal Metabolite

storage

+4°C

References

[1] J H BIRKINSHAW  H R. Studies in the biochemistry of micro-organisms: Palitantin, C(14)H(22)O(4), a hitherto undescribed metabolic product of Penicillium palitans Westling.[J]. Biochemical Journal, 1936, 30 5: 801-808. DOI: 10.1042/bj0300801
[2] HUIXIAO HONG. Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching?[J]. Journal of Medicinal Chemistry, 1997, 40 6: 930-936. DOI: 10.1021/jm960754h
[3] KRISTIAN F. NIELSEN*. Dereplication of Microbial Natural Products by LC-DAD-TOFMS[J]. Journal of Natural Products , 2011, 74 11: 2338-2348. DOI: 10.1021/np200254t

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