tripchlorolide Usage And Synthesis

Uses

Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].

References

[1] Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37. DOI:10.1006/exnr.2002.8049
[2] Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70. DOI:10.3892/ijo.2011.1278
[3] Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. J Neurochem. 2015 Apr;133(1):38-52. DOI:10.1111/jnc.13056

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