voacristine Chemical Properties

Melting point:

112-114 °C

Boiling point:

542.9±50.0 °C(Predicted)

Density 

1.32±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml

form 

A crystalline solid

pka

14.94±0.20(Predicted)

voacristine Usage And Synthesis

Uses

(?)-Voacangarine is an indole alkaloid, which exhibits cytotoxic effects against cancer cells HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 of 5~20 mg/mL. (?)-Voacangarine inhibits the cultivation of Saccharomyces cerevisiae wildtype and repair-deficient mutants[1][2].

References

[1] Melo AA, et al., Cytostatic, cytotoxic and mutagenic effects of voacristine, an indole alkaloid in wild-type and repair-deficient yeasts. Mutat Res. 1986 Jul;171(1):17-24. DOI:10.1016/0165-1218(86)90004-2

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