agrimol B
agrimol B Basic information
- Product Name:
- agrimol B
- Synonyms:
-
- agrimol B
- (2S)-1-[3,5-Bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone
- (S)-(+)-Agrimol B
- AGRIMOL B(P)
- 1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphenyl)-2-methyl-, (S)-
- 1-Butanone,1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-,(2S)-
- Agrimol B (-)-Agrimol B
- 1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphe
- CAS:
- 55576-66-4
- MF:
- C37H46O12
- MW:
- 682.75
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 55576-66-4.mol
agrimol B Chemical Properties
- Boiling point:
- 922.6±65.0 °C(Predicted)
- Density
- 1.292
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 7.09±0.50(Predicted)
- color
- White to yellow
- InChIKey
- BVLHMPZMQVWDGX-INIZCTEOSA-N
- SMILES
- C(C1=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C(O)C(CC2=C(O)C(C(=O)CCC)=C(OC)C(C)=C2O)=C1O)(=O)[C@@H](C)CC
agrimol B Usage And Synthesis
Chemical Properties
White crystalline powder, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Agrimony.
Uses
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27[1][2][3].
Biological Activity
Agrimol B, a polyphenol derivative isolated from Agrimony, inhibits adipogenesis, induces the translocation and expression of SIRT1, and reduces the expression of PPARγ.
in vivo
Agrimol B (10 mg/kg, Orally, daily) reduces growth of prostate cancer cell xenograft in mice[2].
| Animal Model: | BALB/c nude mice (6-week-old, male, injected with PC-3 cells in 0.2 mL PBS subcutaneously)[2] |
| Dosage: | 10 mg/kg |
| Administration: | Orally, daily, after 15 days of cancer cell implantation |
| Result: | Inhibited tumor growth in a mouse model of human prostate cancer, reduced the tumor volume at day 31 and day 32. |
target
PPAR | Antifection
IC 50
SIRT1; PPARγ
References
[1] Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. DOI:10.1016/j.bbrc.2016.06.078
[2] Hnit SST, et al. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. DOI:10.1016/j.biopha.2021.111795
[3] Chun S B, et al. Antibacterial Activities against Plant Pathogens and Identification of Agrimol B from Agrimonia pilosa LEDEB[J]. ?????? ?10? 3?, 2006, 10(3):230-236.
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