perlapine Chemical Properties

Melting point:

136-138°

Boiling point:

423.4°C (rough estimate)

Density 

1.0521 (rough estimate)

refractive index 

1.6080 (estimate)

storage temp. 

Store at -20°C

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml

form 

A crystalline solid

pka

8.00±0.20(Predicted)

color 

White

Safety Information

Toxicity

LD50 in male, female mice, rats (mg/kg): 61, 61, 60, 66 i.v.; 250, 300, 480, 420 s.c., 270, 280, 660, 720 orally (Yokotani)

perlapine Usage And Synthesis

Uses

Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively). Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing. Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.

Uses

Perlapine exhibits antipsychotic activity and blocks dopamine and serotonin receptors. Perlapine is also a novel agonist of hM3Dq, a designer receptor exclusively activated by designer drugs (DREADD).

Definition

ChEBI: Perlapine is an organic molecular entity.

storage

Room temperature

perlapine(1977-11-3)Related Product Information

• FLUPERLAPINE
• 2-ETHYL-BENZAMIDINE
• perlapine
• 1-(2-METHYLBENZYL)PIPERAZINE