1-Butanesulfonyl chloride Chemical Properties

Melting point:

-29°C

Boiling point:

80-81 °C/9 mmHg (lit.)

Density 

1.208 g/mL at 25 °C (lit.)

vapor pressure 

0.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.454(lit.)

Flash point:

175 °F

form 

Liquid

color 

Clear colorless to light yellow or light orange

Water Solubility 

DECOMPOSES

Sensitive 

Moisture Sensitive

BRN 

1748742

InChIKey

WEDIIKBPDQQQJU-UHFFFAOYSA-N

CAS DataBase Reference

2386-60-9(CAS DataBase Reference)

NIST Chemistry Reference

1-Butanesulfonyl chloride(2386-60-9)

EPA Substance Registry System

1-Butanesulfonyl chloride (2386-60-9)

Safety Information

Hazard Codes 

C

Risk Statements 

34-36/37

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

RTECS 

EK5950000

F 

10-19-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Toxicity

mouse,LD50,intraperitoneal,> 100mg/kg (100mg/kg),Nature. Vol. 174, Pg. 737, 1954.

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Butanesulfonyl chloride Usage And Synthesis

Description

1-Butanesulfonyl chloride is an antimicrobial agent that inhibits the production of inflammatory substances. It has been shown to inhibit acetylcholinesterase activity and the growth of cancer cells in vitro. 1-Butanesulfonyl chloride is a cross-linking agent that can be used to produce amides, which are used as pharmaceutical preparations for treating inflammatory diseases.

Chemical Properties

clear colourless to light yellow liquid

Uses

1-Butanesulfonyl chloride has been used in the preparation of:

• ethyl 2-(1-butanesulfonamido)pent-4-yn-l-oate
• 1-butanesulfonamid-N,N′-1,2-ethanediylbis
• 1-butanesulfonamide-N,N′-1,3-propanediylbis

Purification Methods

It has a pungent odour and is LACHRYMATORY. If IR shows OH bands, then dissolve in Et2O, wash with cold saturated aqueous NaHCO3 (care since CO2 will be generated) then H2O, dry it over solid Na2SO4, filter, evaporate and distil the residue twice. Characterise it by shaking a solution in Et2O or *C6H6 with aqueous NH3, collect the solid 1-butanesulfonamide with m 48o after recrystallisation from CHCl3, CCl4 or Et2O/pet ether. [Douglass & Johnson J Am Chem Soc 60 1488 1938, Lee & Dougherty J Org Chem 5 83 1940, Beilstein 4 IV 45.]

1-Butanesulfonyl chloride(2386-60-9)Related Product Information

• Sodium chloride
• Thionyl chloride
• Zinc chloride
• alpha-Toluenesulfonyl chloride
• Choline chloride
• Oxalyl chloride
• Sulfuryl chloride
• 4-Nitrobenzenesulfonyl chloride
• N-Acetylsulfanilyl chloride
• Benzenesulfonyl chloride
• Chloromethanesulfonyl chloride
• Ethanesulfonyl chloride
• Cyclopropanesulfonyl chloride
• Calcium chloride
• Potassium chloride
• 4-tert-Butylbenzenesulfonyl chloride
• Tosyl chloride
• Ammonium chloride