tribendimidine
tribendimidine Basic information
- Product Name:
- tribendimidine
- Synonyms:
-
- tribendimidine
- Ethanimidamide, N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-
- N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide
- N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)
- N'-(4-{[(4-{[(4-{[1-(dimethylamino)ethylidene]amino}phenyl)imino]methyl}phenyl)methylidene]amino}phenyl)-N,N-dimethylethanimidamide
- Tribendimidine, 10 mM in DMSO
- N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)
- CAS:
- 115103-15-6
- MF:
- C28H32N6
- MW:
- 452.59
- EINECS:
- 620-470-6
- Mol File:
- 115103-15-6.mol
tribendimidine Chemical Properties
- Boiling point:
- 618.2±65.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 12.31±0.15(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3
- InChIKey
- XOIOGKHKNQYULW-UHFFFAOYSA-N
- SMILES
- C1(C=NC2=CC=C(N=C(N(C)C)C)C=C2)=CC=C(C=NC2=CC=C(N=C(N(C)C)C)C=C2)C=C1
tribendimidine Usage And Synthesis
Uses
Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3].
in vivo
Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters[2].
| Animal Model: | C. sinensis infected Female Wistar rats[2] |
| Dosage: | 75 mg/kg and 150 mg/kg |
| Administration: | Oral administration, once |
| Result: | A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg. |
References
[1] Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. DOI:10.1016/j.actatropica.2005.01.013
[2] Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. DOI:10.1128/AAC.01366-06
[3] Hu Y, et al. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. DOI:10.1371/journal.pntd.0000499
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