Actisomide
Actisomide Basic information
- Product Name:
- Actisomide
- Synonyms:
-
- Actisomide
- (4R,4aR)-4-[2-(Diisopropylamino)ethyl]-1-methyl-4-phenyl-4,4a,5,6 ,7,8-hexahydro-3H-pyrido[1,2-c]pyrimidin-3-one
- (+/-)-trans-4-<2-
ethyl>-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-3H-pyrido<1,2-c>-pyrimidin-3-one - 3H-Pyrido[1,2-c]pyrimidin-3-one, 4-[2-[bis(1-methylethyl)amino]ethyl]-4,4a,5,6,7,8-hexahydro-1-methyl-4-phenyl-, (4R,4aR)-rel-
- CAS:
- 96914-39-5
- MF:
- C23H35N3O
- MW:
- 369.54
- Mol File:
- 96914-39-5.mol
Actisomide Chemical Properties
- Melting point:
- 201-202 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 473.9±55.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- pka
- 10.51±0.28(Predicted)
Actisomide Usage And Synthesis
Originator
Dizactamide ,ZYF Pharm Chemical
Manufacturing Process
Hydrogenation of 4-diisopropylamino-2-phenyl-2-pyridin-2-yl-butyramide over
platinum oxide catalyst reduced the pyridine ring to a piperidine to give 4-
diisopropylamino-2-phenyl-2-piperidin-2-yl-butyramide as a white solid, MP:
107°-108°C. Structure was confirmed by proton, carbon-13-NMR spectra and
by elemental analysis.
2-(1-Acetylpiperidin-2-yl)-4-diisopropylamino-2-phenylbutyramide was
prepared by acetylation of above product with N,N-dimethylacetamide
dimethylacetal by heating at 80°C for about 14 hours. The acetamide melted
at 191°-192°C. The treatment of that intermediate with lithium aluminum
hydride led the newly introduced acetyl group to condense with the adjacent
amide nitrogen. There was thus obtained 4-(2-diisopropylaminoethyl)-1-
methyl-4-phenyl-4,4a,5,6,7,8-hexahydropyrido[1,2-c]pyrimidin-3-one, the
new anti-arrhythmic agent actisomide, MP: 70°-75°C. Its structure was
confirmed by proton NMR and infrared spectra and by elemental analysis.
brand name
Cardiac depressant (anti-arrhythmic).
Therapeutic Function
Cardiac depressant