TETRACHLOROHYDROQUINONE Chemical Properties

Melting point:

238-240 °C

Boiling point:

352.31°C (rough estimate)

Density 

1.8232 (rough estimate)

refractive index 

1.4813 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Sparingly), Methanol (Slightly, Heated)

pka

5.54±0.33(Predicted)

form 

Solid

color 

Off-White to Light Orange

Water Solubility 

21.5mg/L(temperature not stated)

CAS DataBase Reference

87-87-6(CAS DataBase Reference)

EPA Substance Registry System

2,3,5,6-Tetrachlorohydroquinone (87-87-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-36/37/39-39

RTECS 

MX7700000

HS Code 

2914.79.4000

MSDS

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TETRACHLOROHYDROQUINONE Usage And Synthesis

Description

Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC₅₀ = 1.55 μM in a neutral red assay). TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of the mitochondrial membrane potential and necrosis in splenocytes. In vivo, TCHQ induces glutathione (GSH) depletion in mouse liver.

Chemical Properties

LIGHT BEIGE CRYSTALLINE POWDER

Uses

Tetrachlorohydroquinone is a chlorinated hydroquinone compound used as an analytical standard.

Definition

ChEBI: A tetrachlorobenzene that is 1,2,4,5-tetrachlorobenzene in which the hydrogens at positions 3 and 6 are replaced by hydroxy groups.

Purification Methods

Crystallise the quinone from EtOH or AcOH/EtOH. Sublime it at 77o/0.6x10-3mm. The dibenzoyl derivative has m 233o. [Conant & Fieser J Am Chem Soc 45 2207 1923, Rabideau et al. J Am Chem Soc 108 8130 1986, Beilstein 6 H 851, 6 I 417, 6 II 846, 6 III 4436, 6 IV 5775.]

TETRACHLOROHYDROQUINONE(87-87-6)Related Product Information

• Dibutyl phthalate
• Calcium chloride
• Sodium peroxide
• DITHIANON
• 2,6-Dichlorophenol
• 2,3,6-TRICHLOROPHENOL
• 2,3,5-TRICHLOROPHENOL
• 2,5-Dichlorophenol
• TETRACHLOROHYDROQUINONE
• 1,2,4,5-Tetrachlorobenzene
• 3,5-Dichlorophenol
• 2,5-DICHLOROHYDROQUINONE
• 2,3,5,6-TETRACHLOROPHENOL
• Chlorohydroquinone
• 2,3-Dichlorophenol
• Tetrachlorohydroquinone dimethyl ether
• 2,6-DICHLORO-1,4-HYDROQUINONE
• 4-hydroxynonachlorodiphenyl ether