9-keto Fluprostenol isopropyl ester Chemical Properties

Boiling point:

583.6±50.0 °C(Predicted)

Density 

1.241±0.06 g/cm3(Predicted)

solubility 

DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml

pka

13.32±0.20(Predicted)

9-keto Fluprostenol isopropyl ester Usage And Synthesis

Uses

9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).

Uses

Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.

9-keto Fluprostenol isopropyl ester(1219032-18-4)Related Product Information

• Iodoethane
• Ethyl bromoacetate
• 15(S)-Fluprostenol isopropyl ester
• Travoprost
• 15-KETO FLUPROSTENOL
• 5,6-trans Travoprost
• 3-Trifluoromethylphenol
• 15-Keto Travoprost
• (+)-Fluprostenol
• (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide
• 15(S)-FLUPROSTENOL
• 9-KETO FLUPROSTENOL
• Fluprostenol