ECHINOCANDIN B Chemical Properties

Melting point:

>190oC (dec.)

Boiling point:

1330.8±65.0 °C(Predicted)

Density 

1.60

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.86±0.26(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

InChIKey

BLKJKIJFNJAQIZ-DVQJIADUNA-N

ECHINOCANDIN B Usage And Synthesis

Uses

Echinocandin B is a lipopeptide antifungal agent produced by several species of Aspergillus.

Synthesis

A method for the preparation of high purity EchinocandinB, comprising the steps of:

1) solid-liquid separation of Echinocandin B fermentation broth to obtain a solid fermentation culture;

2) Addition of polar solvents to the solid fermentation culture for maceration;

3) solid-liquid separation of the soaking solution to obtain echinocandin B extract;

4) The extract with toned-down polar solvent concentration was introduced into a macroporous adsorbent resin for enrichment;

5) After adsorption, the resin was washed with a gradient polar solvent and then desorbed with a desorbent;

6) Decolorize the desorbed solution, stir well and filter;

7) The decolorized solution was concentrated, extracted and crystallized to obtain the crude extract of echinocandin B;

8) The crude extract was separated by Fraclite 800 chromatography to obtain the high-purity echinocandin B product.

ECHINOCANDIN B(79411-15-7)Related Product Information

• 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1)
• 2-AMINO-1-BUTANOL
• Butyl stearate
• 1b
• Boron
• Polymyxin B
• Pimecrolimus
• Tacrolimus
• Micafungin
• Itraconazole
• Terconazole