SUBEROSIN Chemical Properties

Melting point:

87.5 °C(Solv: methanol (67-56-1))

Boiling point:

158-172 °C(Press: 0.05 Torr)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Cryst.

color 

White to off-white

LogP

3.870 (est)

SUBEROSIN Usage And Synthesis

Chemical Properties

Soluble in methanol, ethanol, DMSO and other organic solvents, from white solanaceous, white pair of cotyledons (for the leaves of the Cornusaceae plant (Mulai) wood).

Uses

Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB[1][2].

Definition

ChEBI: A natural product found in Citropsis articulata.

References

[1] Y-C Chen, et al. Suberosin inhibits proliferation of human peripheral blood mononuclear cells through the modulation of the transcription factors NF-AT and NF-jB. British Journal of Pharmacology (2007) 150, 298-312.
[2] Golfakhrabadi F, et al. Anticoagulant activity of isolated coumarins (suberosin and suberenol) and toxicity evaluation of Ferulago carduchorum in rats. Pharm Biol. 2014 Oct;52(10):1335-40. DOI:10.3109/13880209.2014.892140

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