2-METHOXYACETAMIDINE HYDROCHLORIDE Chemical Properties

Melting point:

70 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light yellow to yellow Solid-Liquid Mixture

2-METHOXYACETAMIDINE HYDROCHLORIDE Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-methoxyacetimidic acid ethyl ester hydrochloride as 2-methoxyacetamidine hydrochloride: ethanol (500 mL) was cooled to -15°C and anhydrous ammonia was passed through the mixture with stirring until the mixture was saturated. Ethyl 2-methoxyacetimidate hydrochloride (90 g, 585 mmol) was added and the reaction mixture was stirred at room temperature overnight. Subsequently, the mixture was cooled again to -15°C and a small amount of insoluble solid was removed by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was crystallized during standing to give 2-methoxyacetamidine hydrochloride (70 g, 96% yield). The product was characterized by 1H NMR (360 MHz, DMSO-d6): δ 3.35 (3H, s), 4.24 (2H, s), 8.85 (4H, br s).

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 22, p. 4251 - 4260
[2] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 47
[3] Patent: WO2006/44732, 2006, A2. Location in patent: Page/Page column 213
[4] Patent: WO2008/39882, 2008, A1. Location in patent: Page/Page column 212
[5] Patent: WO2008/39882, 2008, A1. Location in patent: Page/Page column 212

2-METHOXYACETAMIDINE HYDROCHLORIDE(1903-91-9)Related Product Information

• OXYPHENCYCLIMINE
• 2-(2-[2-(2,4-DICHLOROPHENOXY)ETHANIMIDOYL]HYDRAZINO)-2-OXOACETAMIDE
• 2-(2,3-DIHYDRO-2-METHOXY-1,4-BENZODIOXIN-2-YL)-4,5-DIHYDRO-1H-IMIDAZOLE HYDROCHLORIDE
• EFAROXAN HYDROCHLORIDE
• IDAZOXAN HYDROCHLORIDE
• 3-AMINO-2-[(2,4-DICHLOROPHENOXY)METHYL]-3,4-DIHYDROQUINAZOLIN-4-ONE
• N'-(2,4-DICHLOROPHENYL)-2-[(1-PHENYL-1H-1,2,4-TRIAZOL-3-YL)OXY]ETHANIMIDOHYDRAZIDE
• N'-[2-(4-CHLOROPHENOXY)ETHANIMIDOYL]-5-METHYL-3-PHENYL-4-ISOXAZOLECARBOHYDRAZIDE
• 2-(2-CHLORO-2-METHYLPHENOXY)-1-(HYDROXYIMINO)ETHYLAMINE
• N'-[2-(4-CHLOROPHENOXY)ETHANIMIDOYL]-2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ACETOHYDRAZIDE
• 4-(2,4-DICHLOROBENZOYL)-1-METHYL-N'-(2-PHENOXYETHANIMIDOYL)-1H-PYRROLE-2-CARBOHYDRAZIDE
• 3-(2-CHLOROPHENYL)-5-METHYL-N'-(2-[3-(TRIFLUOROMETHYL)PHENOXY]ETHANIMIDOYL)-4-ISOXAZOLECARBOHYDRAZIDE
• 2-(3-CHLOROPHENOXY)-N'-(6-CHLORO-2-PYRIDINYL)ETHANEHYDRAZONAMIDE
• N'-(4-CHLOROBENZOYL)-2-(2,4-DICHLOROPHENOXY)ETHANEHYDRAZONAMIDE
• N'-[2-(4-CHLOROPHENOXY)ETHANIMIDOYL]-3-(2-CHLOROPHENYL)-5-METHYL-4-ISOXAZOLECARBOHYDRAZIDE
• N'-[2-(4-CHLOROPHENOXY)ETHANIMIDOYL]-4-(2,4-DICHLOROBENZOYL)-1-METHYL-1H-PYRROLE-2-CARBOHYDRAZIDE
• 4-(2,4-DICHLOROBENZOYL)-N'-[2-(4-FLUOROPHENOXY)ETHANIMIDOYL]-1-METHYL-1H-PYRROLE-2-CARBOHYDRAZIDE
• 2-(3-CHLOROPHENOXY)-N'-ISONICOTINOYLETHANEHYDRAZONAMIDE