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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Basic information Safety Supplier Related

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Basic information

Product Name:
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
Synonyms:
  • BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)-
  • (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
  • (S)-1-(2,6-dichloro-4-fluorophenyl)ethanol
  • (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
  • (aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol
  • -1-(2,6-Dichloro-3-fluorophenyl)
  • (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
  • (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
CAS:
877397-65-4
MF:
C8H7Cl2FO
MW:
209.04
EINECS:
700-699-9
Product Categories:
  • Aromatic Ring
  • Chiral Compounds
Mol File:
877397-65-4.mol
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemical Properties

Boiling point:
261.3±35.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
13.30±0.20(Predicted)
form 
Solid
color 
White
InChI
InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
InChIKey
JAOYKRSASYNDGH-UFLUHPNLNA-N
SMILES
[C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
CAS DataBase Reference
877397-65-4
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Safety Information

HazardClass 
IRRITANT
HS Code 
2906290090
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Usage And Synthesis

Uses

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor ( c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

Uses

(S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK).

Uses

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

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