4-NITROQUINOLINE N-OXIDE Chemical Properties

Melting point:

154-156 °C(lit.)

Boiling point:

325.64°C (rough estimate)

Density 

1.42

refractive index 

1.5570 (estimate)

storage temp. 

-20°C

solubility 

acetone: clear to hazy

form 

Crystalline Solid

pka

-1.83±0.10(Predicted)

color 

yellow to brown

BRN 

165756

Stability:

Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.

InChIKey

YHQDZJICGQWFHK-UHFFFAOYSA-N

CAS DataBase Reference

56-57-5(CAS DataBase Reference)

EPA Substance Registry System

4-Nitroquinoline 1-oxide (56-57-5)

Safety Information

Hazard Codes 

T

Risk Statements 

45-68-40-20/21/22

Safety Statements 

53-45-36/37-22

RIDADR 

2811

WGK Germany 

3

RTECS 

VC2100000

HazardClass 

6.1

PackingGroup 

II

HS Code 

29339900

Hazardous Substances Data

56-57-5(Hazardous Substances Data)

Toxicity

LD50 intraperitoneal in mouse: 190mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-NITROQUINOLINE N-OXIDE Usage And Synthesis

Chemical Properties

yellow-brown crystals or powder

Uses

4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation.

Uses

4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

Definition

ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4.

General Description

Yellowish-brown plates or needles or yellow solid.

Air & Water Reactions

4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water.

Reactivity Profile

4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents.

Health Hazard

ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible.

Biochem/physiol Actions

Skin and lung tumor initiator under experimental conditions.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplas tigenic, and tumorigenic data. Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.]

4-NITROQUINOLINE N-OXIDE(56-57-5)Related Product Information

• 4-NITROQUINOLINE N-OXIDE
• Quinoline-N-oxide
• 4-NITROQUINOLINE
• 6-METHYL-4-NITROQUINOLINE-1-OXIDE
• 3-methyl-4-nitroquinoline 1-oxide,3-METHYL-4-NITROQUINOLINE N-OXIDE
• 8-METHYL-4-NITROQUINOLINE-1-OXIDE
• 2-methyl-4-nitroquinoline 1-oxide
• 3-Nitroquinoline 1-oxide
• 7-Nitroquinoline 1-oxide
• nitroquinoline N-oxide reductase
• 5-NITROQUINOLINE 1-OXIDE
• 4-NITROQUINOLINE-N-OXIDE SOLUTION 100UG/ML IN METHANOL 5ML
• 4-(Hydroxyamino)-6-nitroquinoline 1-oxide
• 6,7-DICHLORO-4-NITROQUINOLINE-1-OXIDE
• PYRIDINES MIXTURE
• 7-Methyl-4-nitroquinoline 1-oxide
• 4-NITROQUINOLINE-N-OXIDE, [3-3H]
• 6-Butyl-4-nitroquinoline 1-oxide