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4-NITROQUINOLINE N-OXIDE

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4-NITROQUINOLINE N-OXIDE Basic information

Product Name:
4-NITROQUINOLINE N-OXIDE
Synonyms:
  • TIMTEC-BB SBB006266
  • 4-nitrochinolinn-oxid
  • 4-nitrochinolinn-oxid(swedish)
  • 4-nitro-quinolin1-oxide
  • 4-nitroquinolineoxide
  • 4-nqo
  • nitrochin
  • Quinoline, 4-nitro-, 1-oxide
CAS:
56-57-5
MF:
C9H6N2O3
MW:
190.16
EINECS:
200-281-1
Product Categories:
  • pharmacetical
  • Nitroquinolines
  • Quinolines
Mol File:
56-57-5.mol
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4-NITROQUINOLINE N-OXIDE Chemical Properties

Melting point:
154-156 °C(lit.)
Boiling point:
325.64°C (rough estimate)
Density 
1.42
refractive index 
1.5570 (estimate)
storage temp. 
-20°C
solubility 
acetone: clear to hazy
form 
Crystalline Solid
pka
-1.83±0.10(Predicted)
color 
yellow to brown
BRN 
165756
Stability:
Stable. Hygroscopic, light-sensitive. Incompatible with strong oxidizing agents.
InChIKey
YHQDZJICGQWFHK-UHFFFAOYSA-N
CAS DataBase Reference
56-57-5(CAS DataBase Reference)
EPA Substance Registry System
4-Nitroquinoline 1-oxide (56-57-5)
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Safety Information

Hazard Codes 
T
Risk Statements 
45-68-40-20/21/22
Safety Statements 
53-45-36/37-22
RIDADR 
2811
WGK Germany 
3
RTECS 
VC2100000
HazardClass 
6.1
PackingGroup 
II
HS Code 
29339900
Hazardous Substances Data
56-57-5(Hazardous Substances Data)
Toxicity
LD50 intraperitoneal in mouse: 190mg/kg

MSDS

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4-NITROQUINOLINE N-OXIDE Usage And Synthesis

Chemical Properties

yellow-brown crystals or powder

Uses

4-Nitroquinoline N-Oxide is used in method for constructing animal model of oral mucosal malignancy related to Kras mutation.

Uses

4-Nitroquinoline N-oxide has been used as a model compound to study its carcinogenic effects.

Definition

ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4.

General Description

Yellowish-brown plates or needles or yellow solid.

Air & Water Reactions

4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water.

Reactivity Profile

4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents.

Health Hazard

ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.

Fire Hazard

Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible.

Biochem/physiol Actions

Skin and lung tumor initiator under experimental conditions.

Safety Profile

Suspected carcinogen with experimental carcinogenic, neoplas tigenic, and tumorigenic data. Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.]

4-NITROQUINOLINE N-OXIDESupplier

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