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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE

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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Basic information

Product Name:
3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
Synonyms:
  • IMidazo[1,2-b]pyridazine, 3-broMo-
  • 3-BroMoiMidazo[1,2-b]pyri...
  • 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
  • 3-broMoiMidazo(1,2-b)pyridazin
  • 3-Bromoimidazo[1,2-b]pyridazine
  • Ponatinib Impurity 2
  • Ponatinib intermediate
  • 3-Bromoimidazo[1,2-b]pyridazine >
CAS:
18087-73-5
MF:
C6H4BrN3
MW:
198.02
Mol File:
18087-73-5.mol
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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Chemical Properties

Melting point:
148.0 to 152.0 °C
Density 
1.89
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.35±0.30(Predicted)
color 
White to Light yellow
CAS DataBase Reference
18087-73-5
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
HS Code 
29339900
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3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Usage And Synthesis

Uses

3-Bromoimidazo[1,2-B]pyridazine is a pharmaceutical intermediate compound. It is used in the preparation of Ponatinib, a tyrosine kinase inhibitor (TKI), which is used in the treatment of chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL).

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