befiradol
befiradol Basic information
- Product Name:
- befiradol
- Synonyms:
-
- befiradol
- 1-(3-Chloro-4-fluorobenzoyl)-4-fluoro-N-[(5-methyl-2-pyridinyl)methyl]-4-piperidinemethanamine
- Unii-rat9oha1yh
- F 13640
- (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
- Befiradol (F 13640
- NLX 112)
- Methanone, (3-chloro-4-fluorophenyl)[4-fluoro-4-[[[(5-methyl-2-pyridinyl)methyl]amino]methyl]-1-piperidinyl]-
- CAS:
- 208110-64-9
- MF:
- C20H22ClF2N3O
- MW:
- 393.86
- Mol File:
- 208110-64-9.mol
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befiradol Chemical Properties
- Boiling point:
- 536.9±50.0 °C(Predicted)
- Density
- 1.30
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.01±0.20(Predicted)
- form
- Solid
- color
- White to off-white
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befiradol Usage And Synthesis
Uses
Befiradol (NLX-112) is a selective 5-HT1A receptor agonist.
Biological Activity
NLX-112 (also known as befiradol or F13640) is a highly selective 5-HT1A receptor full agonist with >1000-fold selectivity compared to other types of receptors. It has been investigated for the treatment of Parkinsonμs disease patients who exhibit L-DOPA-induced dyskinesia
IC 50
5-HT1A Receptor
References
[1] Lladó-Pelfort L, et al. In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre- and postsynaptic 5-HT1A receptors in the rat. Psychopharmacology (Berl). 2012 May;221(2):261-72. DOI:10.1007/s00213-011-2569-9
befiradolSupplier
Shanghai Fuhe Chemistry Technology Co., Ltd.
- Tel
- 0086-21-67651709
- cfx759@hotmail.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Fan De(Beijing) Biotechnology Co., Ltd.
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- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
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