7BETA-HYDROXYCHOLESTEROL Chemical Properties

Melting point:

165-167?C

Boiling point:

515.3±38.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

pka

14.11±0.70(Predicted)

color 

White to Off-White

InChIKey

OYXZMSRRJOYLLO-RIMZZQGGNA-N

SMILES

[C@@]12([H])CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@H](O)CC3=C[C@H](O)[C@@]21[H] |&1:0,4,5,13,17,19,23,28,30,r|

Safety Information

Safety Statements 

22-26

WGK Germany 

-

HS Code 

29062990

MSDS

• Language:English Provider:SigmaAldrich

7BETA-HYDROXYCHOLESTEROL Usage And Synthesis

Chemical Properties

White Solid

Uses

7β-hydroxycholesterol was used to study oxysterol-induced apoptosis in human endothelial cells.

Definition

ChEBI: 7beta-hydroxycholesterol is an oxysterol and a 7beta-hydroxy steroid. It is functionally related to a cholesterol.

Biological Activity

7β-Hydroxycholesterol is an oxysterol, the enzymatic or non-enzymatic product of cholesterol oxidation. Oxysterols are cytotoxic and induce death in monocytes, smooth muscle cells and endothelial cells. The mechanism of apoptosis induced by oxysterols may involve caspases or DNA fragmentation. Increased levels of 7β-Hydroxycholesterol correlates with increased risk of cardiovascular diseases including atherosclerosis.

IC 50

IL-1β

7BETA-HYDROXYCHOLESTEROL(566-27-8)Related Product Information

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