N-Desethyl Sunitinib Chemical Properties

Melting point:

268-270?C

Boiling point:

574.4±50.0 °C(Predicted)

Density 

1.265±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly, Heated), Methanol (Sparingly)

form 

Solid

pka

11.71±0.20(Predicted)

color 

Yellow to Dark Yellow

InChI

InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-

InChIKey

LIZNIAKSBJKPQC-GDNBJRDFSA-N

SMILES

N1C(/C=C2/C3=C(NC/2=O)C=CC(F)=C3)=C(C)C(C(NCCNCC)=O)=C1C

N-Desethyl Sunitinib Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

A metabolite of Sunitinib (S820000).

Biological Activity

N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor th at is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patients, plasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%, respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib.

N-Desethyl Sunitinib(356068-97-8)Related Product Information

• N,N-Dimethyl Sunitinib
• N-Desethylsunitinib hydrochloride
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• SU 5416
• 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
• SU 11274
• SU5402
• Lacosamide
• De-5-fluoro 4-FluorochidaMide
• 2,4-DIMETHYL PYRROL-3-CARBALDEHYDE
• Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
• 5-Fluoro-2-oxindole
• Pyrrole-2,4-dicarboxaldehyde, 3,5-dimethyl- (6CI,7CI,8CI)
• Sunitinib iMpurity
• Sunitinib N-Oxide
• Sunitinib Malate
• Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
• N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide