2-(2-Bromoethyl)-1,3-dioxolane Chemical Properties

Boiling point:

68-70 °C8 mm Hg(lit.)

Density 

1.542 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.479(lit.)

Flash point:

149 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Ethyl Acetate (Slightly)

form 

clear liquid

Specific Gravity

1.541.542

color 

brownish-yellow

Water Solubility 

immiscible

Sensitive 

Light Sensitive

BRN 

103516

InChIKey

GGZQLTVZPOGLCC-UHFFFAOYSA-N

CAS DataBase Reference

18742-02-4(CAS DataBase Reference)

NIST Chemistry Reference

2-(2-Bromoethyl)-1,3-dioxolane(18742-02-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-37/39

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

2

F 

8-9

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29329990

MSDS

• Language:English Provider:3-Bromopropionaldehyde ethylene acetal
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-(2-Bromoethyl)-1,3-dioxolane Usage And Synthesis

Chemical Properties

Clear colorless to yellow or brown liquid

Uses

Alkylating agent for amines,1 dithianes,2 and carboximides,3 and via the Grignard reagent, aldehydes.4

Uses

2-(2-Bromoethyl)-1,3-dioxolane is used as a pharmaceutical intermediate, dioxolanes, acetals, ketals, building blocks, chemical synthesis, organic building blocks and oxygen compounds. 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures. It is also used as flavouring agent.

General Description

Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride affords the key organotrifluoroborate reagent.

Purification Methods

Dissolve it in pentane, wash with 5% aqueous NaHCO3, dry (Na2SO4), and evaporate. Distil the residue. [NMR: Büchi & Wüest J Org Chem 34 1122 1969, Kriesat & Gisvold J Pharm Sci 60 1250 1971, Beilstein 19/1 V 69.]

2-(2-Bromoethyl)-1,3-dioxolane(18742-02-4)Related Product Information

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