6-Chlorouracil Chemical Properties

Melting point:

290-295°C

Boiling point:

300°C

Density 

1.61±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in Ammonium Hydroxide

form 

Solid

pka

6.24±0.10(Predicted)

color 

White

Water Solubility 

4.885g/L(25 ºC)

BRN 

120492

InChI

InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9)

InChIKey

PKUFNWPSFCOSLU-UHFFFAOYSA-N

SMILES

C1(=O)NC(Cl)=CC(=O)N1

CAS DataBase Reference

4270-27-3(CAS DataBase Reference)

NIST Chemistry Reference

6-Chlorouracil(4270-27-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

6-Chlorouracil Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases.

Uses

Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

6-Chlorouracil(4270-27-3)Related Product Information

• Uracil
• Difluorochloromethane
• 5-CHLOROURACIL,5-CHLORO-2,4-DIHYDROXYPYRIMIDINE,5-CHLOROURACIL CRYSTALLINE,5-Chlorouracil,98%,5-CHLOROURACIL
• 3-Methyl-6-chlorouracil, GC 97%,3-METHYL-6-CHLOROURACIL
• 1,3-Dimethyl-4-chlorouracil,1,3-DIMETHYL-6-CHLOROURACIL
• 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE
• 5-Chlorouridine
• 6-methyl-5-chlorouracil
• 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE
• 3,5-Diethyl-1-allyl-6-chlorouracil,1-Allyl-3,5-diethyl-6-chlorouracil
• 6-Chloro-5-Nitropyrimidine-2,4-Diol
• 5-ETHYL-6-CHLOROURACIL
• 1,3-Dimethyl-5-chlorouracil
• 1-(3-Fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-chlorouracil
• 5-Chlorouracil-15N2,13C
• 6-Chlorouracil
• 6-CHLORO-3-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-2,4(1H,3H)-PYRIMIDINEDIONE
• 6-CHLORO-1-ETHYL-3-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE