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Tetrahydropalmatine

Basic information Description References Safety Supplier Related

Tetrahydropalmatine Basic information

Product Name:
Tetrahydropalmatine
Synonyms:
  • AKOS 208-04
  • L-TETRAHYDROPALMATINE
  • L-TETRAHYDROPALMATINE HCL
  • TETRAHYDROPALMATINE
  • ROTUNDINE
  • ROTUNDIN HYDRATE
  • ROTUNDINUM
  • g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-6h-dibenzo(
CAS:
10097-84-4
MF:
C21H25NO4
MW:
355.43
EINECS:
1592732-453-0
Product Categories:
  • chemical reagent
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Plant extracts
  • Alkaloids
  • Miscellaneous Natural Products
  • Pharmaceutical intermediate
Mol File:
10097-84-4.mol
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Tetrahydropalmatine Chemical Properties

CAS DataBase Reference
10097-84-4(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
HS Code 
29339900
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Tetrahydropalmatine Usage And Synthesis

Description

Tetrahydropalmatine (THP) is an isoquinoline alkaloid found in in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda (Qian Jin Teng). These plants exhibits analgesic, antinociceptive, anxiolytic, antidepressant, and anti-parasitic activities, and have traditional uses in Chinese herbal medicine. In particular, the levo isomer of THP (l-THP) appears to contribute to many of the therapeutic effects of these herbs. Notably, the dextro isomer of THP has distinct pharmacological actions that include depletion of monoamines and may contribute to the toxicology profile of THP-containing preparations or racemic mixtures of the compound. In addition to serving as an active constituent in traditional Chinese herbal preparations, purified or synthetic l-THP is approved for use and available as Rotundine or Rotundin in China, where l-THP has been used as an analgesic and sedative for more than 40 years.

References

1. https://en.wikipedia.org/wiki/Tetrahydropalmatine
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878639/
3.https://www.worldseedsupply.com/product/corydalis-yanhusuo-tetrahydropalmatine-98-pure-thp-isolate/
4. https://www.lktlabs.com/product/dl-tetrahydropalmatine/

Purification Methods

Crystallise it from MeOH or EtOH by addition of water [see Kametani & Ihara J Chem Soc (C) 530 1967, Bradsher & Dutta J Org Chem 26 2231 1961]. When crystallised from Me2CO/Et2O, it has m 142o. The hydrate has m 115o(effervescence). The picrate has m 188o(dec) (from aqueous EtOH). [Bradsher & Datta J Org Chem 26 2231 1961, Beilstein 21 II 196, 21 III/IV 2769.]

TetrahydropalmatineSupplier

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