HEXADECANOIC ACID-1-13C Chemical Properties

Melting point:

61-64 °C(lit.)

Boiling point:

271.5 °C100 mm Hg(lit.)

Density 

0.855 g/mL at 25 °C

storage temp. 

Store at -20°C

solubility 

DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.25 mg/ml

form 

A solid

color 

White to off-white

CAS Number Unlabeled

57-10-3

CAS Number Unlabeled

57-10-3

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

HEXADECANOIC ACID-1-13C Usage And Synthesis

Description

Palmitic acid-¹³C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively. Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellular proteins, promotes protein-vesicle interactions, and regulates various G protein-coupled receptor functions. Red blood cell palmitic acid levels are increased in patients with metabolic syndrome compared to patients without metabolic syndrome and are also increased in the plasma of patients with type 2 diabetes compared to individuals without diabetes.

Uses

Hexadecanoic-1-13C Acid is a labeled analog of Palmitic Acid (P144500), which is a common fatty acid found in plants and animals. The body converts excess carbohydrates into Palmitic Acid, thus Palmitic Acid is the first fatty acid produced during fatty acid synthesis as well as a precursor for longer fatty acids.

References

[1] SARWAT FATIMA. Palmitic acid is an intracellular signaling molecule involved in disease development.[J]. Cellular and Molecular Life Sciences, 2019, 76 13: 2547-2557. DOI: 10.1007/s00018-019-03092-7
[2] M J SANTOS. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients.[J]. Annals of Nutrition and Metabolism, 1995, 39 1: 52-62. DOI: 10.1159/000177842
[3] LUN-ZHAO YI. Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA[J]. FEBS Letters, 2006, 580 30: 6837-6845. DOI: 10.1016/j.febslet.2006.11.043
[4] EDMOND K KABAGAMBE. Erythrocyte fatty acid composition and the metabolic syndrome: a National Heart, Lung, and Blood Institute GOLDN study.[J]. Clinical chemistry, 2008: 154-162. DOI: 10.1373/clinchem.2007.095059

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