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Direct Blue 53

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Direct Blue 53 Basic information

Product Name:
Direct Blue 53
Synonyms:
  • EVANS BLUE C.I. No 23860
  • EvansBlue,99%
  • DiazoBlue
  • 1,3-Naphthalenedisulfonic acid, 6,6-(3,3-dimethyl1,1-biphenyl-4,4-diyl)bis(azo)bis4-amino-5-hydroxy-, tetrasodium salt
  • 4,4'-Bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3'-bitolyl tetrasodium salt
  • 6,6'-[(3,3'-Dimethyl-4,4'-biphenylylene)bis(azo)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid] tetrasodium salt
  • 6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid disodium)
  • 3-[[4'-[(4-Amino-2-methyl-5-methoxyphenyl)azo]-3,3'-dimethoxy-1,1'-biphenyl-4-yl]azo]-4-hydroxynaphthalene-1,5-disulfonic acid disodium salt
CAS:
314-13-6
MF:
C34H24N6Na4O14S4
MW:
960.81
EINECS:
206-242-5
Product Categories:
  • MATULANE
  • Biological Dye
  • Glutamate receptor
  • Organics
Mol File:
314-13-6.mol
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Direct Blue 53 Chemical Properties

storage temp. 
Store at RT.
Colour Index 
23860
form 
Powder/Solid
color 
Dark Brown
Water Solubility 
280 g/L (20 ºC)
Merck 
14,3905
Stability:
Stable. Incompatible with strong reducing agents, strong oxidizing agents.
CAS DataBase Reference
314-13-6
IARC
3 (Vol. 8, Sup 7) 1987
EPA Substance Registry System
C.I. Direct Blue 53 (314-13-6)
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Safety Information

Hazard Codes 
T,F
Risk Statements 
45-63-11-61-20/21/22
Safety Statements 
53-45-36/37-16-36/37/39
WGK Germany 
3
RTECS 
QJ6440000
TSCA 
Yes
HS Code 
32129000
Toxicity
LD50 intraperitoneal in mouse: 340mg/kg

MSDS

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Direct Blue 53 Usage And Synthesis

Chemical Properties

brownish crystalline powder

Uses

antineoplastic

Definition

ChEBI: An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppr ss background autofluorescence.

General Description

Blue crystals with a greenish-bronze luster or a black powder.

Air & Water Reactions

Azo dyes can be explosive when suspended in air at specific concentrations. Soluble in water.

Reactivity Profile

Direct Blue 53 is an azo compound. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Direct Blue 53 can react with strong reducing and oxidizing agents.

Fire Hazard

Flash point data for Direct Blue 53 are unavailable; however, Direct Blue 53 is probably combustible.

Biological Activity

Potent inhibitor of L-glutamate uptake into synaptic vesicles. Also inhibits AMPA and kainate receptor-mediated currents (IC 50 values are 220 and 150 nM respectively). P2X-selective purinoceptor antagonist.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by intravenous route. An experimentalteratogen. Other experimental reproductive effects.Questionable carcinogen with experimental tumorigenicdata. Mutation data reported. When heated todecomposition it

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