Isosorbide Chemical Properties

Melting point:

60-63 °C (lit.)

alpha 

42 º (c=3, H2O)

Boiling point:

175°C/2mmHg(lit.)

Density 

1.0945 (rough estimate)

vapor pressure 

0.007Pa at 20℃

refractive index 

45 ° (C=5, H2O)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

pka

13.17±0.40(Predicted)

form 

Crystals, Crystalline Solid or Mass

color 

Off-white to light yellow or beige

optical activity

[α]20/D +45.2°, c = 3 in H2O

Water Solubility 

Soluble in alcohols, water and ketones.

Sensitive 

Hygroscopic

Merck 

14,5224

BRN 

80510

InChIKey

KLDXJTOLSGUMSJ-JGWLITMVSA-N

LogP

-1.39 at 20℃

CAS DataBase Reference

652-67-5(CAS DataBase Reference)

EPA Substance Registry System

D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

Safety Information

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

2

RTECS 

LZ4380000

TSCA 

Yes

HS Code 

29349990

Hazardous Substances Data

652-67-5(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Isosorbide Usage And Synthesis

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Isosorbide(652-67-5)Related Product Information

• Sorbitol
• Isosorbide dinitrate
• D(+)-Glucose
• Isosorbide dimethyl ether
• Ammonium carbonate
• Isosorbide-2-Acetate
• ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE
• ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0%,isosorbide2-nitrat
• Isostearic Acid
• isononyl alcohol
• 1,4-ANHYDRO-D-GLUCITOL
• Octadecyl isocyanate
• 3-Methyl-1-butanol
• Isosorbide-13C6 2-Mononitrate,Isosorbide-13C6 2-Nitrate
• 2-CHLOROETHYL ISOTHIOCYANATE
• ISOCYANIC ACID
• FIXATEUR ITC
• Potassium 2-ethylhexanoate