Isosorbide Chemical Properties

Melting point:

60-63 °C (lit.)

alpha 

42 º (c=3, H2O)

Boiling point:

175°C/2mmHg(lit.)

Density 

1.0945 (rough estimate)

vapor pressure 

0.007Pa at 20℃

refractive index 

45 ° (C=5, H2O)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Crystals, Crystalline Solid or Mass

pka

13.17±0.40(Predicted)

color 

Off-white to light yellow or beige

optical activity

[α]20/D +45.2°, c = 3 in H2O

Water Solubility 

Soluble in alcohols, water and ketones.

Sensitive 

Hygroscopic

Merck 

14,5224

BRN 

80510

Cosmetics Ingredients Functions

SKIN CONDITIONING
HUMECTANT

InChI

1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1

InChIKey

KLDXJTOLSGUMSJ-JGWLITMVSA-N

SMILES

O[C@H]1CO[C@@H]2[C@H](O)CO[C@H]12

LogP

-1.39 at 20℃

CAS DataBase Reference

652-67-5(CAS DataBase Reference)

EPA Substance Registry System

D-Glucitol, 1,4:3,6-dianhydro- (652-67-5)

Safety Information

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

2

RTECS 

LZ4380000

TSCA 

TSCA listed

HS Code 

29349990

Storage Class

11 - Combustible Solids

Hazardous Substances Data

652-67-5(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Isosorbide Usage And Synthesis

Chemical Properties

off-white to light yellow or beige crystals,

Uses

pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives; the nitrate esters find use as vasodilators and coronary disease therapeutics.

Uses

D-Isosorbide is used as a reagent in the preparation of detergents, agrochemicals, cleansers, cosmetics and vasodilators. It is also employed as a pharmaceutical intermediate for dimethyl ether and mono- and dinitrate derivatives, which is used as vasodilators and coronary disease therapeutics. It is used in the treatment of hydrocephalus and glaucoma. It finds application as a building block for polymers like polycarbonates and polyesters.

Uses

Isosorbide is a reagent widely used to prepare detergents, cleansers, cosmetics, agrochemicals and vasodilators.

Definition

A polyol with a hydroxyl group attached to each of two cis-oriented saturated furan rings. Intermediate for pharmaceuticals. Combustible.

brand name

Ismotic (Alcon).

Biological Functions

emergency treatment of acute angle-closure glaucoma. It should not be confused with isosorbide dinitrate, an antianginal drug.

Flammability and Explosibility

Non flammable

Clinical Use

Isosorbide is basically a bicyclic form of sorbitol that is used orally to cause a reduction in intraocular pressure in glaucoma cases. Although a diuretic effect is noted, its ophthalmologic properties are its primary value.

Synthesis

Isosorbide can be obtained by catalytic dehydration of sorbitol, sorbitol can be converted from starch, sucrose, glucose and other renewable resources, and has long been large-scale industrialized production, process maturity, cheap.

Isosorbide(652-67-5)Related Product Information

• Isosorbide dinitrate
• D(+)-Glucose
• Isosorbide dimethyl ether
• Ammonium carbonate
• Isosorbide-2-Acetate
• ISOSORBIDE MONONITRATE,ISOSORBIDE 5-NITRATE,ISOSORBIDE 5-MONONITRATE, 98.5%,ISOSORBIDE MONO ACETATE,ISOSORBIDE 5-MONONITRATE,5-ISOSORBIDE MONONITRATE
• ISOSORBIDE 2-MONONITRATE,ISOSORBIDE 2-MONONITRATE 99-101.0%,isosorbide2-nitrat
• Isostearic Acid
• isononyl alcohol
• 1,4-ANHYDRO-D-GLUCITOL
• Octadecyl isocyanate
• 3-Methyl-1-butanol
• Sorbitol
• Isosorbide-13C6 2-Mononitrate,Isosorbide-13C6 2-Nitrate
• 2-CHLOROETHYL ISOTHIOCYANATE
• ISOCYANIC ACID
• FIXATEUR ITC
• Potassium 2-ethylhexanoate