4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE Chemical Properties

Melting point:

166-167 °C (sublm)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

color 

White to Light yellow

InChIKey

NVTBASMQHFMANH-UHFFFAOYSA-N

CAS DataBase Reference

7709-58-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-41-22

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2934100090

4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White crystalline

Uses

4-(Chloromethyl)thiazole hydrochloride and its derivatives can be used to prepare 4-thiazole carboxylic acid. It has been shown that in the study of synthesis of conformationally restricted RGD-containing integrin ligands by efficient solid-phase intramolecular thioalkylation, the reaction of S-nucleophiles with the newly generated N-terminal 4-chloromethyl thiazoles afforded the desired cyclic RGD product 5 with high purity and good overall yield^[1].

References

[1] ADEL NEFZI  Jason E F. N-terminus 4-chloromethyl thiazole peptide as a macrocyclization tool in the synthesis of cyclic peptides: application to the synthesis of conformationally constrained RGD-containing integrin ligands[J]. Tetrahedron Letters, 2011. DOI:10.1016/j.tetlet.2010.12.043.

4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE(7709-58-2)Related Product Information

• 2-AMINO-4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE,2-Amino-4-(chloromethyl)-1,3-thiazole hydrochloride
• 2-Methyl-4-(chloromethyl)thiazole Hydrochloride
• 4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
• 4-(CHLOROMETHYL)-2-(4-CHLOROPHENYL)-1,3-THIAZOLE
• 2-(2,6-DICHLOROBENZYL)-1,3-THIAZOLE-4-CARBONYL CHLORIDE
• 2-(2,3-DICHLOROPHENYL)-1,3-THIAZOLE-4-CARBONYL CHLORIDE
• 2-DIMETHYL AMINO METHYL-4-CHLORO METHYL THIAZOLE HCL
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• Methyl 2-(chloromethyl)thiazole-4-carboxylate
• 2-CHLORO-5-(CHLOROMETHYL)-1,3-THIAZOLE[FOR THIAMETHOXAM],2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE
• 2-CHLOROMETHYL-THIAZOLE
• N-[4-(CHLOROMETHYL)-1,3-THIAZOL-2-YL]-N-(3-CHLOROPHENYL)ACETAMIDE
• 4-(CHLOROMETHYL)-2-(3-CHLOROPHENYL)-1,3-THIAZOLE HYDROCHLORIDE
• 4-(CHLOROMETHYL)-2-(2-CHLOROPHENYL)-1,3-THIAZOLE
• 4-(CHLOROMETHYL)-2-PHENYL-1,3-THIAZOLE HYDROCHLORIDE
• 4-(CHLOROMETHYL)-N-(2-METHYLPHENYL)-1,3-THIAZOL-2-AMINE HYDROCHLORIDE