N-Acetyl-L-phenylalanine Chemical Properties

Melting point:

171-173 °C(lit.)

alpha 

40 º (c=1,methanol)

Boiling point:

346.25°C (rough estimate)

Density 

1.1878 (rough estimate)

refractive index 

40 ° (C=5, MeOH)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Solubility in methanol (almost transparency). Soluble in acetone and ethanol (20 mg/ ml).

form 

Fine Crystalline Powder or Needles

pka

3.56±0.10(Predicted)

color 

White to off-white

optical activity

[α]22/D +40.0°, c = 1 in methanol

InChIKey

CBQJSKKFNMDLON-JTQLQIEISA-N

CAS DataBase Reference

2018-61-3(CAS DataBase Reference)

NIST Chemistry Reference

L-phenylalanine, n-acetyl-(2018-61-3)

EPA Substance Registry System

L-Phenylalanine, N-acetyl- (2018-61-3)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29242990

MSDS

• Language:English Provider:L-2-(Acetylamino)-3-phenylpropanoic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-Acetyl-L-phenylalanine Usage And Synthesis

Chemical Properties

white to off-white fine cryst. powder or needles

Uses

It is an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of aspartame. It is applied as an antidepressant.

Uses

N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.

Definition

ChEBI: The N-acetyl derivative of L-phenylalanine.

General Description

N-Acetyl-L-phenylalanine is an acetyl analog of L-phenylalanine. It is widely used as a reactant to synthesize methyl or ethyl esters of N-acetyl-L-phenylalanine, which are employed as versatile building blocks in peptide synthesis.

Purification Methods

N-Acetyl-L-phenylalanine is recrystallised from H2O, 20% MeOH/H2O, or CHCl3; dry and store it at 4o. The (DL)-isomer crystallises from H2O, Me2CO, EtOAc, or CHCl3 with m 152-154o and the solubilities in w% at 25o are 0.73 (H2O), 4.3 (Me2CO), 0.79 (EtOAc) and 0.34 (CHCl3) [Kerr & Niemann J Org Chem 23 893 1958, Overby & Ingersoll J Am Chem Soc 73 3363 1951, L: Fu et al. J Am Chem Soc 76 6057 1954, Bender & Glasson J Am Chem Soc 81 1591 1959]. [Beilstein 14 I 238, 4 IV 1575.]

N-Acetyl-L-phenylalanine(2018-61-3)Related Product Information

• Folic acid
• Citric acid
• D-Phenylalanine
• N-(tert-Butoxycarbonyl)-L-phenylalanine
• Acetylacetone
• DL-Phenylalanine
• Phenprobamate
• Acetyl coenzyme A sodium salt
• Ethyl 2-(Chlorosulfonyl)acetate
• L-Phenylalanine
• Ascoric Acid
• Melphalan
• N-Acetyl-3,5-diiodo-L-tyrosine
• CHLOROACETYL-L-TYROSINE
• Aspartame
• N-Glycyl-L-tyrosine
• Ethyl N-acetyl-L-tyrosinate hydrate
• N-CBZ-VAL-TYR METHYL ESTER