Ethyl nitroacetate Chemical Properties

Boiling point:

105-107 °C/25 mmHg (lit.)

Density 

1.199 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.424(lit.)

Flash point:

198 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

pka

pK1:5.85 (25°C)

form 

Liquid

color 

Clear colorless to slightly yellow

Water Solubility 

Slightly soluble in water. Soluble in chloroform and ethyl acetate.

BRN 

1210027

InChIKey

FTKASJMIPSSXBP-UHFFFAOYSA-N

CAS DataBase Reference

626-35-7(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, nitro-, ethyl ester(626-35-7)

EPA Substance Registry System

Acetic acid, nitro-, ethyl ester (626-35-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

38

Safety Statements 

23-24/25-37

WGK Germany 

2

RTECS 

AJ1074000

Hazard Note 

Irritant

TSCA 

T

HazardClass 

IRRITANT, KEEP COLD

HS Code 

29159080

MSDS

• Language:English Provider:Ethyl nitroacetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl nitroacetate Usage And Synthesis

Chemical Properties

clear colourless to slightly yellow liquid

Uses

Ethyl nitroacetate has been used in the synthesis of γ-oxoacids via Michael addition reaction with α,β-unsaturated ketones, fuctionalization of C4-position on pyrimidine and C6-position on 2?-deoxyguanosine to produce novel nucleosides, facile synthesis of α,α-diisobutylglycine, synthesis of DL-4,4-difluoroglutamic acid. It is also used as an intermediate in the preparation of unsubstituted amino acids.

Uses

Ethyl Nitroacetate is an ester of nitrocarboxylic acid used as an intermediate in the preparation of unsubstituted amino acids.

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 1208, 1994 DOI: 10.1021/jo00084a047

Purification Methods

Purify the ester by repeated distillation. IR:max 1748 (CO2), 1570 and 1337 (NO2), and 800cm-1 [Haszeldine J Chem Soc 2525 1953]. The hydrazine salt crystallises from 95% EtOH or MeOH as yellow crystals m 104-105o [Ungnade & Kissinger J Org Chem 22 1661 1957, Emmons & Freeman J Am Chem Soc 77 4391 1955]. [Beilstein 2 IV 537.]

Ethyl nitroacetate(626-35-7)Related Product Information

• Ethanol
• Ethyl acetate
• Ethylparaben
• ISOXADIFEN-ETHYL
• 2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER
• Ethyl hydrazinoacetate hydrochloride
• Ethyl bromoacetate
• Ethyl phenylacetate
• Ethyl cyanoacetate
• Ethyl propiolate
• Ethyl acrylate
• ETHYL (METHYLTHIO)ACETATE
• Trinexapac-ethyl
• Diethyl nitromalonate
• Methyl vanillate
• Cadmium diethyldithiocarbamate
• Methyl nitroacetate
• Bromoacetaldehyde diethyl acetal