(S)-1-N-Boc-2-(aminomethyl)pyrrolidine Chemical Properties

Boiling point:

98-112℃/1mm

Density 

1.044±0.06 g/cm3(Predicted)

refractive index 

1.4670-1.4710

storage temp. 

2-8°C

solubility 

Miscible with N-methylpyrrolidinone.

pka

9.91±0.29(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

8905233

CAS DataBase Reference

119020-01-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,C

Risk Statements 

36/37/38-51/53-34-22

Safety Statements 

26-36/37/39-61-45

RIDADR 

3259

WGK Germany 

3

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29339900

(S)-1-N-Boc-2-(aminomethyl)pyrrolidine Usage And Synthesis

Chemical Properties

Solid

Uses

(S)-2-Aminomethyl-1-Boc-pyrrolidine acts as an intermediate in organic synthesis. It is also used as a chiral and heterocyclic building block in synthetic chemistry.

Synthesis

GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with an eluent ratio of methanol-dichloromethane (9:1).

References

[1] Synthesis, 2005, # 14, p. 2407 - 2413
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11382 - 11385
[3] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[4] Tetrahedron Letters, 2010, vol. 51, # 40, p. 5281 - 5286
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2013, vol. 188, # 4, p. 509 - 511

(S)-1-N-Boc-2-(aminomethyl)pyrrolidine(119020-01-8)Related Product Information

• Methyl anthranilate
• POLYURETHANE
• N-Vinyl-2-pyrrolidone
• tert-Butyl acetate
• Diisobutyl phthalate
• Butyl acetate
• Cyhalofop-butyl
• BUTYL OLEATE
• Buprofezin
• Urethane
• Diethylene glycol monobutyl ether
• Polyvinylpyrrolidone
• N-Methyl-2-pyrrolidone
• Pyrrolidine
• tert-Butanol
• 4-Aminobenzoic acid
• 2-Butoxyethanol
• Butyl acrylate