Homatropine Hydrobromide Chemical Properties

Melting point:

214-217 °C

storage temp. 

2-8°C

solubility 

Freely soluble in water, sparingly soluble in alcohol.

form 

Solid

color 

White to Off-White

Water Solubility 

soluble

Merck 

14,4730

CAS DataBase Reference

51-56-9(CAS DataBase Reference)

EPA Substance Registry System

Homatropine hydrobromide (51-56-9)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25

Safety Statements 

45-24/25-22

RIDADR 

1544

WGK Germany 

3

RTECS 

YM5602000

HazardClass 

6.1

PackingGroup 

III

HS Code 

29399900

MSDS

• Language:English Provider:alpha-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide
• Language:English Provider:ACROS

Homatropine Hydrobromide Usage And Synthesis

Description

Homatropine is an anticholinergic agent. It reduces acetylcholine-induced contractions of isolated goat detrusor muscle strips when used at a concentration of 5 μM. Homatropine (1 μM) inhibits acetylcholine- or methacholine-induced contraction of isolated rat anococcygeus muscle. It inhibits serotonin- or thrombin-induced platelet aggregation in isolated sheep platelet-rich plasma (IC₅₀s = 4.3 and 100 μM, respectively). Topical ophthalmic administration of homatropine induces partial mydriasis in Angora goats.

Chemical Properties

white crystals or crystalline powder

Uses

Homatropine is an anticholinergic agent. Homatropine acts as an inhibitor of the muscarinic acetylcholine receptors. Homatropine is used in eye drops as a cycloplegic and as a mydriatic, to dilate the pupil.

Uses

anticholinergic (opthalmic)

brand name

Isopto Homatropine (Alcon) .

General Description

Homatropine hydrobromide,1 H,5 H-tropan-3 -ol mandelate (ester) hydrobromide(Homatrocel), occurs as white crystals or as awhite, crystalline powder that is affected by light. It is solublein water (1:6) and alcohol (1:40), less soluble in chloroform(1:420), and insoluble in ether.
Solutions are incompatible with alkaline substances,which precipitate the free base, and with the commonreagents that precipitate alkaloids. As with atropine, solutionsare sterilized best by filtration through a bacteriologicalfilter.

Clinical Use

Homatropine hydrobromide is used topically to paralyzethe ciliary structure of the eye (cycloplegia) and to effectmydriasis. It behaves very much like atropine but is weakerand less toxic. In the eye, it acts more rapidly but less persistentlythan atropine. Dilation of the pupil takes place inabout 15 to 20 minutes, and the action subsides in about24 hours. By using a miotic, such as physostigmine, it ispossible to restore the pupil to normality in a few hours.

References

[1] N. GEORGE. Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle[J]. Autonomic and Autacoid Pharmacology, 2010, 30 3: 173-177. DOI: 10.1111/j.1474-8673.2009.00447.x
[2] DOGGRELL S A. Effect of antimuscarinic agents on the contractile responses to cholinomimetics in the rat anococcygeus muscle.[J]. British Journal of Pharmacology, 1981, 73 4: 829-835. DOI: 10.1111/j.1476-5381.1981.tb08735.x
[3] F MICHAL  F P. Inhibition of serotonin-induced platelet aggregation in relation to thrombus production.[J]. Journal of Pharmacology and Experimental Therapeutics, 1969, 166 2: 276-284.
[4] N C WHELAN  I L  F Castillo Alcala. Efficacy of tropicamide, homatropine, cyclopentolate, atropine and hyoscine as mydriatics in Angora goats.[J]. New Zealand veterinary journal, 2011, 59 6: 328-331. DOI: 10.1080/00480169.2011.609476

Homatropine Hydrobromide(51-56-9)Related Product Information

• N-Acetyl-L-cysteine
• 4-Aminobenzoic acid
• Dacarbazine
• Serotonin hydrochloride
• Bromoacetyl bromide
• Dichloroacetic acid
• Cisatracurium besylate
• Pilocarpine nitrate
• Tetracaine hydrochloride
• Scopolamine
• HOMATROPINE METHYL BROMIDE
• Homatropine Hydrobromide
• Flutropium bromide
• Tropine
• HOMATROPINE
• Atropine
• tropenziline bromide
• (+)-HOMATROPINE METHYLBROMIDE