Ethyl 6-aminonicotinate Chemical Properties

Melting point:

145-147

Boiling point:

314.7±22.0 °C(Predicted)

Density 

1.192±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

4.88±0.13(Predicted)

Appearance

Off-white to light brown Solid

CAS DataBase Reference

39658-41-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

Hazard Note 

Irritant

HS Code 

2933399990

Ethyl 6-aminonicotinate Usage And Synthesis

Synthesis

To a suspension of 1.3 g (9.4 mmol) 6-aminonicotinic acid in 100 mL of ethanol, was bubbled in dry hydrochloric acid at 0° C., then the solution was refluxed until all the solids dissolved. The solvents were removed under reduced pressure, the residue dissolved in ethyl acetate, washed with saturated sodium bicarbonate, brine, and concentrated to afford 1.37 g of a white solid Ethyl 6-Aminonicotinate.

References

[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
[2] Patent: WO2007/86080, 2007, A2. Location in patent: Page/Page column 37
[3] Patent: WO2010/3048, 2010, A1. Location in patent: Page/Page column 110
[4] Patent: WO2015/105779, 2015, A1. Location in patent: Page/Page column 11; 12
[5] Patent: US2016/333005, 2016, A1. Location in patent: Paragraph 0042-0043

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