2'-OMe-ibu-G Phosphoramidite
2'-OMe-ibu-G Phosphoramidite Basic information
- Product Name:
- 2'-OMe-ibu-G Phosphoramidite
- Synonyms:
-
- 2’-O-Methy-rG(N-ibu)Phosphoramidite
- N-blocked-5'-O-DMT-2'-O-Me CED guanosine phosphoramidite
- 5'-O-(4,4-Dimethoxytrityl)-2'-O-methyl-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
- 5'-O-DMT-2'-O-Me-rG(N-iBu)-3'-CEDPA
- 2'-OMe-ibu-G Phosphoramidite
- 5'-O-DMT-2'-O-Me-G(ibu) phosporamidite
- DMT-2′O-Methyl-rG(ib) Phosphoramidite
- ibu-2'-OMe-G Phosphoramidite
- CAS:
- 150780-67-9
- MF:
- C45H56N7O9P
- MW:
- 869.94
- EINECS:
- 2017-001-1
- Product Categories:
-
- Amidite
- Mol File:
- 150780-67-9.mol
2'-OMe-ibu-G Phosphoramidite Chemical Properties
- Melting point:
- 138 - 140°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- powder
- pka
- 9.16±0.20(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9)38(61-62(59-25-13-24-46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/s3
- InChIKey
- IRRDHRZUOZNWDJ-MLLDKZSOSA-N
- SMILES
- O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(NC(=N3)NC(=O)C(C)C)=O)N=C2)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,44,47,r|
2'-OMe-ibu-G Phosphoramidite Usage And Synthesis
Chemical Properties
The IUPAC Name is N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
Uses
2''-OMe-ibu-G Phosphoramidite (CAS# 150780-67-9) is used in the synthesis of native-like crosslinked duplex RNA via interstrand crosslinking reaction between vinylpurine on one strand and target cytosine or uracil on the opposite strand.
Definition
2'-OMe-ibu-G Phosphoramidite is a chemically unstable and heat-sensitive nucleoside phosphoramidite that serves as a foundational element in oligonucleotide synthesis. 2'-OMe-RNA CE (β-cyanoethyl) Phosphoramidites are designed to produce synthetic oligonucleotides containing nuclease resistant 2'-O-methyl ribonucleotide linkages. Deprotection, isolation and handling of 2'-O-methyl oligonucleotides are identical to the procedures for oligodeoxynucleotides.
2'-OMe-ibu-G PhosphoramiditeSupplier
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2'-OMe-ibu-G Phosphoramidite(150780-67-9)Related Product Information
- Thiophanate-methyl
- 1,1-Dimethoxyethane
- Methyl salicylate
- Methylene dithiocyanate
- METSULFURON METHYL
- Kresoxim-methyl
- Dimethyldimethoxysilane
- Cyanoacetic acid
- Tribenuron methyl
- Methyl acetate
- 2'-O-(2-Methoxyethyl)uridine
- DMT-2'-O-MOE-rU Phosphoramidite
- 2'-O-MOE-ADENOSINE
- 2'-O-(2-Methoxyethyl)guanosine
- Methyl
- Methyl bromide
- Parathion-methyl
- 2'-OMe-ibu-G Phosphoramidite