(R)-(+)-Dropropizine Chemical Properties

Melting point:

98-100°

alpha 

D25 -10° (c = 1.0 in ethanol)

Boiling point:

412.7±34.0 °C(Predicted)

Density 

1.168±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Acetonitrile (Slightly), Methanol (Slightly)

pka

14.21±0.20(Predicted)

color 

White to Off-White

CAS DataBase Reference

99291-24-4(CAS DataBase Reference)

Safety Information

Toxicity

LD50 in mice, rats (mg/kg): 1287.2, 886.6 orally; 408.0, 401.3 i.p. (Borsa)

(R)-(+)-Dropropizine Usage And Synthesis

Description

Levodropropizine is an antitussive with antiinflammatory activity, the L-isomer of dropropizine. Compared with the racemate, levodropropizine is reported to have less sedative potential and better therapeutic index, while maintaining the the same efficacy levels as an antitussive and antiinflammatory.

Originator

Dompe (Italy)

Uses

receptor agonist, treatment of colds and allergic rhinitis

Uses

R-Form of Dropropizine (D681495). (R)-(+)-Dropropizine is a cough suppressive phenylpiperazine derivative. (R)-(+)-Dropropizine is an antitussive and central sedative therapeutic agent.

brand name

Levotus

(R)-(+)-Dropropizine(99291-24-4)Related Product Information

• 2-Ethylhexyl ferulate
• Phenylhydrazine
• 2-METHYL-1,3-PROPANEDIOL
• Dropropizine
• 1-Methoxy-2-propyl acetate
• Poly(propylene glycol)
• Propylene glycol
• (R)-(-)-1,2-Propanediol
• Hydroxypropyl methyl cellulose
• N-Aminoethylpiperazine
• Diprophylline
• PHENYL VALERATE
• 1-Phenoxy-2-propanol
• Hydroxypropyl cellulose
• 1-Methoxy-2-propanol
• Levonorgestrel
• Levosimendan
• Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate